Longitudinal Remote Sleep and Cognitive Research in Older Adults With Mild Cognitive Impairment and Dementia: Prospective Feasibility Cohort Study
Gabb et al.
The finding, in our words
The study demonstrated that longitudinal remote monitoring using wearable sleep electroencephalography, actigraphy, and self-collected saliva samples is feasible in older adults with mild cognitive impairment or dementia, with high retention and data completeness rates over eight weeks.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
Merck describes a digitally enabled, patient-centric trial initiative that combines outpatient PK/PD sampling with digital biomarkers and smart dosing technologies to improve exposure-response understanding and reduce patient burden, while acknowledging adoption challenges.
Dockendorf et al., Clinical and translational science · source ↗
A US survey of 3,400 adults aged 62 to 90 collected up to 15 biomeasures at home, including saliva, dried blood spots and urine, with Salivette and Oragene among the devices used, which shows that several patient-centric sampling methods can run together in home-based research.
Jaszczak et al., The journals of gerontology. Series B, Psychological sciences and social sciences (paywalled) · source ↗
In progressive multiple sclerosis, higher serum neurofilament light chain levels were associated with reduced daily step counts from wearables, while higher step counts were linked to lower sNfL. A ten percent increase in steps corresponded to a 0.015 decrease in sNfL z-score, suggesting rising sNfL may predict subsequent mobility decline.
Joseph et al., Annals of clinical and translational neurology (paywalled) · source ↗
Older adults with and without cognitive impairment were motivated to participate in longitudinal remote sleep research, finding it acceptable when device burden was low, usability high, and adequate support enabled routine integration. Varying cognitive task content and allowing timing flexibility reduced fatigue, while diverse recruitment remains needed for equitable representation in decentralised dementia trials.
Biswas et al., Journal of medical Internet research · source ↗
Wearable biochemical monitoring requires a complete measurement chain that integrates quality-controlled biofluid sampling, sensor fusion and metadata capture to convert raw sensor outputs into clinically valid digital biomarkers.