Islet Autoantibody Screening Throughout Australia Using In-Home Blood Spot Sampling: 2-Year Outcomes of Type1Screen

Dried blood spot sampling matched venous serum performance for islet autoantibody detection and was considered minimally invasive and convenient by parents and stakeholders, supporting its use for decentralised screening in home or community settings.

Establishing the performance and acceptability of dried blood spot sampling to screen for islet-specific autoantibodies — Faustini et al., Diabetic medicine : a journal of the British Diabetic Association · source ↗

• blood
• dried
• capillary
• dbs
• self-collection
• validation
• venous-agreement
• acceptability
• pediatric

VAMS microsampling found no significant difference from venous blood for tacrolimus in paediatric patients; samples were stable for 14 days, with average difference between paired at-home samples of 0.12 ± 0.94 ng/mL.

VAMS and parallel-reaction-monitoring mass spectrometry for tacrolimus trough measurements at home in paediatric heart-transplant patients — Zhao et al., J. Mass Spectrometry and Advances in the Clinical Lab · source ↗

• vams
• venous-agreement
• acceptability
• blood
• dbs
• tdm
• self-collection
• dried
• capillary
• pediatric
• immunosuppressants
• validation

Clinical validation for tacrolimus and mycophenolic acid monitoring showed that while volumetric absorptive microsampling met analytical criteria after concentration correction, conventional dried blood spots achieved superior adherence to strict clinical criteria, sample quality, and cost efficiency without significant haematocrit bias.

Comparison of conventional dried blood spots and volumetric absorptive microsampling for tacrolimus and mycophenolic acid determination — Paniagua-González et al., Journal of pharmaceutical and biomedical analysis (paywalled) · source ↗

• blood
• dried
• capillary
• vams
• dbs
• neoteryx-mitra
• self-collection
• validation
• venous-agreement
• tdm
• immunosuppressants
• economics
• haematocrit

Guardian-collected capillary dried blood spots were feasible for home monitoring of lamotrigine, and for carbamazepine and valproic acid when conversion factors were applied, with only 4 of 190 comparisons risking a conflicting dose decision and negligible risk of patient harm. Levetiracetam DBS showed high variability against plasma and is recommended only for checking nonadherence, not for dose adjustment.

Dried Blood Spot Self-Sampling by Guardians of Children With Epilepsy Is Feasible: Comparison With Plasma for Multiple Antiepileptic Drugs — Linder et al., Therapeutic drug monitoring (paywalled) · source ↗

• blood
• liquid
• dried
• capillary
• dbs
• self-collection
• validation
• venous-agreement
• pediatric
• tdm

A dried blood spot LC-MS/MS method was validated for therapeutic monitoring of carbamazepine, lamotrigine, levetiracetam and valproic acid. Concentrations from dried blood spots correlated strongly with plasma (R² 0.92) across venous and capillary samples, enabling home self-collection and reducing clinic visits for children with epilepsy.

Carbamazepine, lamotrigine, levetiracetam and valproic acid in dried blood spots with liquid chromatography tandem mass spectrometry; method development and validation — Linder et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled) · source ↗

• blood
• dried
• capillary
• dbs
• self-collection
• validation
• venous-agreement
• pediatric
• tdm