Human papillomavirus genotype and viral load agreement between paired first-void urine and clinician-collected cervical samples

This randomised sub-study found return rates of 10.4% for Colli-Pee, 10.1% for FLOQSwabs and 7.4% for Evalyn-Brush. All devices yielded sufficient DNA with low invalid rates, but the authors noted the study was limited by low overall participation.

Comparison of three different hpv self-sampling tools - a subanalysis of the prospective, randomized hannover self-collection study — Hempel et al., Archives of gynecology and obstetrics · source ↗

• urine
• first-void
• colli-pee
• self-collection
• acceptability
• hpv
• sti

In 498 women living with HIV, self-collected first-void urine and vaginal samples showed 78% high-risk HPV prevalence and good genotype concordance, kappa 0.64-0.78. Participants preferred the Colli-Pee device over the Evalyn Brush, supporting decentralised, patient-centric screening feasibility.

Feasibility of First-Void Urinary and Vaginal Self-Sampling for High-Risk Human Papillomavirus Testing Among Women Living With Human Immunodeficiency Virus in Guinea-Bissau-A Multicenter Cross-Sectional Study — Madsen et al., Journal of medical virology · source ↗

• colli-pee
• acceptability
• first-void
• sti
• self-collection
• hpv
• urine

Urine self-sampling for HPV showed non-inferior specificity to cervical samples, 85.19%, and found 96% of high-grade lesions. While acceptable, a survey of 1382 participants found 41.6% preferred conventional screening, showing the importance of offering choice in a decentralised, patient-centric programme.

Urine human papillomavirus testing for cervical screening in a UK general screening population: a diagnostic test accuracy study — Davies et al., The British journal of general practice : the journal of the Royal College of General Practitioners · source ↗

• urine
• first-void
• colli-pee
• self-collection
• acceptability
• hpv
• sti

In a Belgian colposcopy referral cohort, a study found that 66.6% of women preferred home-based first-void urine self-sampling over physician-taken samples, and 96.6% found the Colli-Pee UCM FV-5010 device easy to use. This supports patient-centric, decentralised screening, though results are limited to this specific referral population.

Home-based urinary HPV self-sampling for the detection of cervical cancer precursor lesions: attitudes and preferences from Belgian females participating in the CASUS study — Hendrickx et al., Archives of public health = Archives belges de sante publique · source ↗

• colli-pee
• acceptability
• first-void
• self-collection
• hpv
• liquid-biopsy
• liquid
• urine

A systematic review of 70 studies found that 94.7% of accuracy studies reported comparable sensitivity and specificity between self-sampling and clinician collection for HPV detection, with patient acceptability ranging from 84.2% to 100% for devices including Colli-Pee. This evidence endorses decentralised cervical screening to improve uptake.

Comparison of diagnostic accuracy and acceptability of self-sampling devices for human Papillomavirus detection: A systematic review — Aimagambetova et al., Preventive medicine reports · source ↗

• urine
• first-void
• colli-pee
• self-collection
• validation
• acceptability
• hpv