2012 · PLoS ONE · open access
Hu et al.
Oragene-stabilised saliva DNA agreed with blood at 98.7% of called markers on a pharmacogenetic array; saliva's lower overall call rate tracked its variable human-DNA content.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
2016
With Oragene DISCOVER self-collection, saliva SNP-array genotypes matched blood at 99.996% concordance; about 6% of samples failed on low yield, so an occasional repeat should be expected.
Saliva DNA quality and genotyping efficiency in a predominantly elderly population — Gudiseva et al., BMC Medical Genomics · source ↗
2016
ORAcollect saliva matched blood at 97.9% overall variant concordance on a hereditary-cancer NGS panel, rising to 100% for protein-coding variants, supporting self-collected saliva for germline testing.
Validation of saliva as an alternative specimen for detecting hereditary breast-cancer mutations by next-generation sequencing — Meghnani et al., International J. Genomics · source ↗
2018
Telomere length measurements vary significantly depending on the sample type used, with Oragene saliva showing a moderate correlation to venous buffy coat, whereas Oasis saliva and dried blood spots did not yield comparable or adequate results for this assay.
Evaluating minimally invasive sample collection methods for telomere length measurement — Goldman et al., American journal of human biology : the official journal of the Human Biology Council (paywalled) · source ↗
2025
This study found that a decontamination pipeline using metagenome-assembled genomes improves the accuracy of variant calling from saliva samples, showing superior concordance with blood-derived results compared to conventional methods. These results validate the potential of self-collected oral samples for accurate personal genotyping.
Metagenome-assembled genomes enhance bacterial read decontamination and variant calling in oral samples — An et al., iScience · source ↗
2018
Both blood and saliva collection methods produced sufficient DNA for genotyping, with saliva using Oragene kits being less invasive and more acceptable for participants who declined blood draws, supporting its use in decentralised research settings
The MOSAICC study: Assessing feasibility for biological sample collection in epidemiology studies and comparison of DNA yields from saliva and whole blood samples — James et al., Annals of human genetics (paywalled) · source ↗