From Home to Transcriptome: Comparing the Transcriptomic Profile of Induced Immune Response via Lipopolysaccharide Stimulation in homeRNA and Venous Blood
Brown et al.
The finding, in our words
The homeRNA capillary blood collection and stabilization platform successfully captured lipopolysaccharide-induced inflammatory gene expression profiles. These transcriptomic responses were comparable to those obtained from traditional venous blood samples stabilized with RNAlater or PAXgene, demonstrating the platform's suitability for remote transcriptomic monitoring.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
The True Dose TD-EPI kit demonstrated strong analytical agreement with venous blood for epirubicin monitoring, and the capillary samples remained stable for 72 hours at ambient temperature.
Self-collected capillary blood samples posted by standard mail showed high concordance with couriered venous samples for HbA1c, creatinine and lipid parameters, supporting their use for remote monitoring in diabetes management and screening.
Plasma lipidomes from self-collected upper-arm capillary blood were statistically indistinguishable from paired venous plasma, most classes at r=0.95–0.99, validating at-home capillary self-collection for lipidomics.
Capillary finger-stick blood showed excellent comparability with venous samples for 30 of 33 routine chemistry analytes against total allowable error criteria, and met CLIA 2024 proficiency testing limits for all but glucose. This validates capillary sampling as a clinically acceptable alternative for most routine tests, benefiting patients with needle phobia and enabling remote sampling.
TAP II capillary serum, both professionally collected and self-collected, correlated with venous serum at R > 0.9 for eight analytes including ALT, AST, cholesterol, HDL and triglycerides. Creatinine correlated acceptably but carried a consistent negative bias, and carbon dioxide, potassium and albumin did not reach acceptable agreement: the useful reading is that the panel has to be validated, not the device alone.