Feasibility, reliability and satisfaction of (automated) capillary carcinoembryonic antigen measurements for future home-based blood sampling: the prospective CASA-I study

This study established conversion methods for estimating plasma concentrations from whole blood VAMS samples for seven out of ten oral anticancer drugs, finding good agreement between capillary and venous samples. Patients reported a positive experience with home sampling using this microsampling technique.

Clinical Application of Volumetric Absorptive Microsampling for Therapeutic Drug Monitoring of Oral Targeted Anticancer Drugs — Meertens et al., Therapeutic drug monitoring · source ↗

• vams
• volumetric
• venous-agreement
• acceptability
• blood
• tdm
• self-collection
• dried
• oncology
• capillary
• validation

VAMS matched serum for the kinase inhibitors nilotinib, cabozantinib, dabrafenib and ruxolitinib, r 0.94–0.97, with serum reliably predictable for the first three, and 93% of at-home samples were collected correctly: at-home VAMS shown feasible for routine cancer-drug monitoring.

Clinical validation and feasibility of VAMS for monitoring of nilotinib, cabozantinib, dabrafenib, trametinib and ruxolitinib — Zimmermann et al., J. Pharmaceutical and Biomedical Analysis (paywalled) · source ↗

• vams
• venous-agreement
• acceptability
• blood
• tdm
• self-collection
• haematocrit
• dried
• oncology
• capillary
• validation

Patients self-collected upper-arm capillary blood with press-activated devices including TAP II; autoantibody and CRP results agreed with venous at r≥0.98, were rated less painful, and 98.6% got enough blood within two attempts.

Remote self-collection of upper-arm capillary blood for autoantibody analysis in immune-mediated rheumatic diseases — Zarbl et al., RMD Open · source ↗

• venous-agreement
• acceptability
• blood
• self-collection
• capillary
• liquid
• yourbio
• biomarkers

The TAP device showed near perfect agreement with venous sampling for anti-Müllerian hormone measurements, with higher accuracy and lower pain compared to ADx card. This validates TAP as a reliable option for patient-led fertility hormone testing at home.

Evaluation of at-home serum anti-Müllerian hormone testing: a head-to-head comparison study — Silliman et al., Reproductive biology and endocrinology : RB&E · source ↗

• venous-agreement
• acceptability
• blood
• self-collection
• capillary
• fertility
• hormones
• yourbio

In AML and CLL, 91% of VAMS venetoclax results fell within 20% of plasma after individualised haematocrit correction; in home sampling, 18 of 21 patients self-sampled independently and 76% of returned samples were analysable, which shows home microsampling is workable, though the authors ask for multicentre validation.

Clinical Validation of Venetoclax Volumetric Microsampling in Leukemia, with Whole-Blood-to-Plasma Conversion and Self-Microsampling Feasibility — Levens et al., Clinical Pharmacokinetics (paywalled) · source ↗

• vams
• venous-agreement
• blood
• dbs
• tdm
• self-collection
• haematocrit
• dried
• oncology
• capillary
• validation