Dried Plasma Spot Based LC-MS/MS Method for Monitoring of Meropenem in the Blood of Treated Patients
Cao et al.
The finding, in our words
A dried plasma spot method for meropenem was validated showing linearity across 0.5–50 µg/mL with acceptable accuracy and precision. Meropenem was more stable in dried plasma spots than wet plasma, and concentrations from 32 patients showed no significant difference between methods. This enables decentralised therapeutic drug monitoring of meropenem by simplifying sample collection and transport while maintaining analytical reliability.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
A UPLC-MS/MS method for linezolid and metabolites in oral fluid and VAMS capillary blood satisfied ICH M10 validation requirements. Linezolid concentrations correlated strongly with venous plasma in both matrices, offering a non‑invasive option for therapeutic drug monitoring, whereas metabolites were systematically underestimated in VAMS and seldom detectable in oral fluid, restricting metabolite measurement.
González-Berdullas et al., Journal of translational medicine (paywalled) · source ↗
The study found that dried blood spot sampling showed good agreement with plasma concentrations for vancomycin and creatinine, with most differences within 20%, and patients preferred the finger prick method over venepuncture, supporting its use for decentralised therapeutic drug monitoring.
Hassanzai et al., The Journal of antimicrobial chemotherapy · source ↗
VAMS finger-prick sampling showed moderate agreement with conventional venous sampling for clofazimine, with a systematic 13% lower concentration that can be corrected, and was more cost-effective by about 4.45 USD per sample, supporting its use for routine therapeutic drug monitoring in MDR-TB.
Nugraha et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled) · source ↗
A structured review: many VAMS assays are analytically validated and can substitute for venous sampling for well-characterised analytes, though clinical-validation depth varies.
Volumetric absorptive microsampling of whole blood did not provide a reliable basis for calculating meropenem plasma concentrations in critically ill children, so a validated low volume plasma method was required for paediatric therapeutic drug monitoring.
Ramadan et al., Therapeutic drug monitoring (paywalled) · source ↗