Dried blood spot characterization of sex-based metabolic responses to acute running exercise
Cendali et al.
The finding, in our words
Capillary dried blood microsampling successfully captured metabolic and lipidomic shifts following acute exercise in healthy volunteers, revealing distinct sex-based differences in carbohydrate and fat utilisation. This confirms the feasibility of using field-deployable dried blood sampling for decentralised multi-omic profiling.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
A comparison of three patient-centric dried blood microsampling devices, paper DBS, Mitra and Tasso-M20, found strong to excellent correlation with traditional venous plasma for measuring branched-chain amino acids and ketoacids. Participants reported high acceptability and expressed a strong willingness to use these devices for decentralised self-collection.
This review evaluates the analytical agreement between blood microsamples and conventional liquid blood, plasma, or serum matrices across targeted and untargeted metabolomic profiling. It highlights haematocrit effects and the analytical validation required to support clinical adoption of patient-centric microsampling.
Thaitumu et al., Analytical science advances · source ↗
Microsampling enables less invasive, patient-centric self-collection of capillary blood for remote monitoring of metabolites and lipids, overcoming conventional venipuncture constraints. Recent device innovations address dried blood spot limitations, particularly haematocrit and volume variations, expanding decentralised applications in population health, drug discovery and multi-omics research.
Microsampling reduces sample volume, invasiveness, logistics and biohazard risk while improving stability and enabling at-home self-sampling, yet clinical adoption remains slow and requires standardisation and harmonisation to realise its patient-centric and decentralised potential.
Thangavelu et al., Analytical science advances · source ↗
A dried blood spot microsampling method measuring over 400 metabolites showed 40% signal loss in the first three months but remained stable thereafter for at least one year when stored at -80°C with desiccants. The method was insensitive to haematocrit between 31-50% and blood volumes above 60 µL, and was clinically validated for diagnosing MELAS, offering a practical alternative to liquid blood for decentralised metabolomic studies.