Development, validation and application of an inductively coupled plasma - mass spectrometry method to determine cobalt in metal-on-metal prosthesis patients using volumetric absorptive microsampling

VAMS gave near‑quantitative recovery for cadmium and lead in human blood and correlated strongly with venous sampling, with pre‑cleaning improving correlation and lowering background lead, supporting its use for decentralised biomonitoring of these toxic elements.

Application of volumetric absorptive microsampling (VAMS) for the simultaneous determination of cadmium and lead in blood — Gutknecht et al., Environmental monitoring and assessment (paywalled) · source ↗

• vams
• venous-agreement
• blood
• dried
• toxicology
• validation

This study validated a method for measuring the alcohol biomarker phosphatidylethanol using two volumetric absorptive microsampling devices, finding that the Mitra device met all validation criteria and agreed with venous sampling. The Capitainer device was deemed suitable but showed reduced accuracy at higher concentrations, with a small proportional negative bias compared to venous results.

A validated method for capillary phosphatidylethanol 16:0/18:1 quantification with two different 10-µl volumetric absorptive microsample devices in the same setup — Andreassen et al., Journal of analytical toxicology (paywalled) · source ↗

• vams
• venous-agreement
• neoteryx-mitra
• blood
• dbs
• dried
• toxicology
• capillary
• validation

A VAMS method using Mitra devices for whole blood lead quantification showed no significant difference compared with the centre's routine method, supporting VAMS as a practical alternative for blood lead and other trace element analyses.

Method development for the quantification of lead levels in whole blood sampled on Mitra^® with VAMS^® tips by inductively coupled plasma-MS/MS — Breton et al., Bioanalysis (paywalled) · source ↗

• blood
• dried
• vams
• neoteryx-mitra
• validation
• venous-agreement
• toxicology

In whole blood spiked with 90 drugs, the VAMS method using the Neoteryx Mitra device confirmed 87 compounds with identification limits below 12.5 ng/mL for 82.2% of drugs and extraction yields of 80.6 to 108.7%. In 15 poisoned patients, 98% of plasma compounds were detected in VAMS with satisfactory concordance (R2 = 0.827), supporting its use for decentralised toxicology screening.

New Trend in Toxicological Screening Using Volumetric Absorptive Microsampling (VAMS) and High-Resolution Mass Spectrometry (HR/MS) Combination — Houzé et al., Molecules · source ↗

• blood
• dried
• vams
• neoteryx-mitra
• validation
• venous-agreement
• toxicology

Capillary VAMS combined with direct mercury analysis demonstrated strong correlation with venous blood mercury concentrations in adult volunteers, with acceptable accuracy and precision above 1.0 µg/l. Storage in pre-cleaned glass vials following two hours of desiccator drying maintained analyte stability for at least four weeks.

Mercury biomonitoring in German adults using volumetric absorptive microsampling — Koutsimpani-Wagner et al., Environmental monitoring and assessment · source ↗

• blood
• dried
• capillary
• vams
• neoteryx-mitra
• validation
• venous-agreement
• toxicology