2026 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · paywalled
Determination of 13 per- and polyfluoroalkyl substances in human plasma samples using LC-MS/MS: application to capillary microsamples
da Luz et al.
The finding, in our words
The authors validated a method to quantify 13 PFAS in human plasma using LC-MS/MS, achieving good precision, accuracy and stability. When applied to 40 paired venous and capillary plasma samples, the capillary microsamples showed high correlation (r = 0.926) with venous samples, confirming their suitability as a less invasive alternative for PFAS biomonitoring in decentralised settings.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
A 2025 review maps 28 microsampling devices, from dried spots and volumetric absorptive tips to upper-arm liquid capillary collectors, and names what a laboratory must control before their results are used: the haematocrit effect in non-volumetric dried samples, interstitial fluid from finger milking, volume, haemolysis and transport stability. Regulators on both sides of the Atlantic ask for the same two things, a device the patient can use safely and a sample fit for the test.
The homeRNA capillary blood collection and stabilization platform successfully captured lipopolysaccharide-induced inflammatory gene expression profiles. These transcriptomic responses were comparable to those obtained from traditional venous blood samples stabilized with RNAlater or PAXgene, demonstrating the platform's suitability for remote transcriptomic monitoring.
Brown et al., Analytical chemistry (paywalled) · source ↗
In pregnant women at high risk of gestational diabetes, the GTT@home capillary glucose device showed a small positive bias of 0.16 mmol/L versus venous laboratory OGTT, with 79.8 per cent of results in the lowest surveillance risk zone and diagnostic classification agreement in 54 of 61 cases, suggesting it could support home OGTT in pregnancy.
The POC haemoglobin device showed moderate correlation with laboratory values but was not accurate enough for routine monitoring; however, it had a high negative predictive value at the 7 g/dL threshold, meaning it can reliably rule out severe anaemia and may help avoid unnecessary transfusions and hospital visits if confirmed in larger studies.
The True Dose TD-EPI kit demonstrated strong analytical agreement with venous blood for epirubicin monitoring, and the capillary samples remained stable for 72 hours at ambient temperature.