2023 · Asian Pacific journal of cancer prevention : APJCP · open access
Comparison of Human Papillomavirus Genotype Detection in Paired Urine and Self-Collected Cervical Swabs: A Pilot Study
Patel et al.
The finding, in our words
This pilot study of women with HPV-positive cervical swabs found urine samples detected high-risk HPV genotypes in 94% (16/17) of cases, achieving 98.8% diagnostic accuracy compared with self-collected cervical swabs. The strong agreement suggests urine testing could support decentralised cervical cancer screening, though larger studies are needed.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
A study of 100 Brazilian women with high-grade cervical lesions found excellent concordance for high-risk HPV detection between clinician-collected samples and patient-centric, self-collected vaginal or first-void urine samples. Self-sampling was preferred for comfort, though the study's single-centre setting may limit generalisability.
The hrHPV ReadyMix qPCR Kit detected high-risk HPV DNA in self-collected urine with 80.9% sensitivity and 100% specificity when compared to cervical swabs. Urine testing identified a similar HPV prevalence (6.28%) to cervical swabs (6.62%), suggesting this non-invasive method could expand cervical cancer screening programmes in low-resource settings.
Self-collected urine samples detected high-risk HPV DNA in 25.5 per cent of women and 8 per cent of men by qPCR, while oral gargle samples detected HPV in 7 per cent of women and 5 per cent of men. With good diagnostic accuracy against Pap smear, qPCR on self-collected specimens offers a viable decentralised approach to HPV screening in remote populations.
Gupta et al., The Indian journal of medical research · source ↗
Urine self-collection detected CIN2/3 with 90.2% sensitivity compared with 93.4% for cervical samples, showing moderate concordance (kappa 0.42) and similar HPV16 detection rates. This validates urine-based HPV screening as a less invasive, patient-centric approach that could expand cervical cancer screening coverage in decentralised healthcare settings.
Buchegger et al., International journal of clinical and experimental pathology (paywalled) · source ↗
In 230 women, HPV detection in self-collected urine showed 90 per cent agreement with cervical sampling (κ=0.80), with 97 per cent concordance for high-risk types. High viral load in urine correlated with cytological abnormalities, suggesting urine self-sampling could enable decentralised cervical cancer screening with good accuracy.
Ducancelle et al., Archives of gynecology and obstetrics (paywalled) · source ↗