Cell-free DNA release following psychosocial and physical stress in women and men
Limberg et al.
The finding, in our words
Capillary blood collected by non-medical personnel and saliva both showed elevated cell-free nuclear DNA after psychosocial and physical stress in women and men, while mitochondrial DNA fragments did not respond consistently. This supports cf-nDNA as a potential decentralised biomarker for acute stress responses, though mechanisms of release remain unclear.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
Noninvasive salivary measurements of creatinine, cystatin C and urea, and fingerstick capillary blood testing, can approximate gold‑standard laboratory results for kidney function. This could enable more frequent, home‑based monitoring to detect CKD progression and AKI episodes without the burdens of conventional venepuncture and laboratory processing.
Beshay et al., Current opinion in nephrology and hypertension (paywalled) · source ↗
In patients with type 2 diabetes and secondary polycythaemia, HbA1c-derived estimated mean plasma glucose showed a significant negative bias compared to structured home capillary blood glucose monitoring, whilst fructosamine served as a more reliable glycaemic marker.
Erarslan et al., Acta diabetologica (paywalled) · source ↗
The homeRNA capillary blood collection and stabilization platform successfully captured lipopolysaccharide-induced inflammatory gene expression profiles. These transcriptomic responses were comparable to those obtained from traditional venous blood samples stabilized with RNAlater or PAXgene, demonstrating the platform's suitability for remote transcriptomic monitoring.
Brown et al., Analytical chemistry (paywalled) · source ↗
A machine learning model called Remote Control was trained on 2685 blood samples to predict change due to instability, enabling accurate calibration of results to approximate the time zero value at collection. With calibration, unprocessed whole blood could be transported for up to 9 days under ambient conditions and temperatures between 3.4 and 47.4 degrees Celsius, achieving agreement with CLIA TEa between 98.1 and 100 per cent and expanding the catalog of tests available for at-home collection.
O'Meara et al., Analytical chemistry (paywalled) · source ↗
Self-collected capillary blood samples posted by standard mail showed high concordance with couriered venous samples for HbA1c, creatinine and lipid parameters, supporting their use for remote monitoring in diabetes management and screening.
Hoffmeister et al., Journal of diabetes investigation · source ↗