Blood Lead Levels in Children 5 to 7 Years of Age from the Republic of Georgia: A Feasibility Study on Lead Surveillance Using Volumetric Absorptive Microsampling

A validated two-step LC-MS/MS protocol can identify 91 prohibited doping agents from a single dried blood spot collected on either cellulose cards or volumetric absorptive microsampling devices. This demonstrates robust multi-analyte screening from capillary blood, supporting decentralised anti-doping programmes where venous sampling is impractical.

Dried Blood Spots for Doping Purpose-Two-Step Protocol for Analysis of Non-Threshold Substances and Anabolic Steroid Esters From One Spot/Pebble — Stojanovic et al., Biomedical chromatography : BMC (paywalled) · source ↗

• blood
• dried
• capillary
• vams
• dbs
• validation
• doping
• toxicology

Capillary blood collected by volumetric absorptive microsampling gave a shorter detection window than urine for a stimulant, helping to distinguish recent from earlier use, and more reliable detection of long-acting diuretics that bind red cells. This shows microsampling can improve interpretation in drug-monitoring programmes where urinary data alone may be ambiguous.

Stressing the limits of capillary blood in anti-doping analysis: perspectives on alkylamine-like stimulants and carbonic anhydrase II inhibitors in result management — da Costa Nunes et al., Frontiers in sports and active living · source ↗

• blood
• dried
• capillary
• vams
• neoteryx-mitra
• doping
• toxicology

PEth reference values for Belgium were derived from VAMS microsampling of 487 participants in a national survey, showing distinct biomarker distributions between the general population and higher‑alcohol‑consumption subgroups. This validates capillary blood collection as a practical method for decentralised alcohol monitoring and forensic assessment.

Reference values for the alcohol biomarker phosphatidylethanol (PEth) in the Belgian population: Insights from a nationwide microsampling study — Vandenbroucke et al., Drug and alcohol dependence reports · source ↗

• vams
• neoteryx-mitra
• blood
• dried
• toxicology
• capillary
• biomarkers

The study developed and validated a rapid LC-MS/MS method for quantifying cefazolin in capillary whole blood collected via VAMS, plasma, and plasma ultrafiltrate, showing robust performance across matrices and successful application in a pediatric pilot cohort for therapeutic drug monitoring.

Rapid, robust LC-MS/MS quantification of cefazolin in whole blood microsamples, plasma, and plasma ultrafiltrate: Analytical method validation and preliminary clinical application in pediatric population — Kocur et al., Clinica chimica acta; international journal of clinical chemistry (paywalled) · source ↗

• vams
• neoteryx-mitra
• blood
• tdm
• haematocrit
• dried
• antimicrobials
• capillary
• pediatric
• validation

This study validated a method for measuring the alcohol biomarker phosphatidylethanol using two volumetric absorptive microsampling devices, finding that the Mitra device met all validation criteria and agreed with venous sampling. The Capitainer device was deemed suitable but showed reduced accuracy at higher concentrations, with a small proportional negative bias compared to venous results.

A validated method for capillary phosphatidylethanol 16:0/18:1 quantification with two different 10-µl volumetric absorptive microsample devices in the same setup — Andreassen et al., Journal of analytical toxicology (paywalled) · source ↗

• vams
• venous-agreement
• neoteryx-mitra
• blood
• dbs
• dried
• toxicology
• capillary
• validation