2023 · Journal of clinical immunology · open access
A Toolkit for Monitoring Immunoglobulin G Levels from Dried Blood Spots of Patients with Primary Immunodeficiencies
Haberstroh et al.
The finding, in our words
In 135 patients with primary immunodeficiency, immunoglobulin G levels from self-collected capillary dried blood spots showed strong correlation and agreement with venous serum, and results were not substantially affected by mailing, supporting remote monitoring of replacement therapy.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
Merck describes a digitally enabled, patient-centric trial initiative that combines outpatient PK/PD sampling with digital biomarkers and smart dosing technologies to improve exposure-response understanding and reduce patient burden, while acknowledging adoption challenges.
Dockendorf et al., Clinical and translational science · source ↗
The Drawbridge OneDraw device enabled home blood collection with high acceptability, as 76 per cent of participants preferred it to finger-prick or venous methods and reported significantly lower pain scores. In a remote study of 4023 participants, sample return rates stayed above 89 per cent across three timepoints over six months, and antibody results agreed well with venous blood in a validation subset of 120 participants.
Koulman et al., Journal of telemedicine and telecare · source ↗
The study found reasonable agreement between finger-prick dried blood spot CRP measurements and venous reference assays in 100 rheumatoid arthritis patients, particularly at low to mid-range CRP values, and showed that weekly self-collected DBS CRP monitoring improved flare detection specificity to 72.7% compared with 54.5% for minimal sampling, supporting decentralised microsampling for remote arthritis management.
In AML and CLL, 91% of VAMS venetoclax results fell within 20% of plasma after individualised haematocrit correction; in home sampling, 18 of 21 patients self-sampled independently and 76% of returned samples were analysable, which shows home microsampling is workable, though the authors ask for multicentre validation.
Levens et al., Clinical Pharmacokinetics (paywalled) · source ↗
Capillary dried blood spots, after haematocrit-dependent conversion, showed good agreement with plasma for 25-hydroxyvitamin D quantification, with 90 per cent of results within 20 per cent of plasma and substantial to almost perfect agreement in status classification, supporting reliable home self-collection for large-scale vitamin D monitoring.
Heughebaert et al., Clinical chemistry and laboratory medicine (paywalled) · source ↗