Wearable perspiration sensor for continuous inflammation tracking in inflammatory bowel disease
Shahub et al.
The finding, in our words
Thirty-three patients with inflammatory bowel disease wore a perspiration sensor that measured C-reactive protein and calprotectin every minute for up to two hours. Sweat measurements were consistent with serum CRP and stool calprotectin, and patterns differed by disease type, age and disease location, demonstrating potential for continuous noninvasive inflammation monitoring.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
This review establishes that microsampling across blood, saliva, urine and stool matrices offers validated workflows and regulatory recognition for human biomonitoring comparable to conventional methods. It finds that these decentralised approaches enhance participant acceptability and enable screening in remote or low-resource settings.
This narrative review finds that saliva is best suited to repeated neuroendocrine and metabolic measurements during exercise, sweat is most mature for electrolyte and sweat-rate monitoring with wearable compatibility, and exhaled breath offers access to volatile metabolism but remains instrumentally demanding. Each matrix requires matching to a defined clinical or exercise question with matrix-specific validation before translational use.
The authors developed a skin-conformal wearable electrochemical sensor that passively collects sweat and simultaneously measures creatine and lactate in real time, using covalent organic frameworks to stabilise the enzymes. In preliminary human studies with healthy individuals and chronic liver disease patients, the platform tracked dynamic changes in these sweat biomarkers, suggesting a route to non-invasive continuous monitoring of liver metabolic function.
Zhao et al., Advanced materials (paywalled) · source ↗
Wearable biochemical monitoring requires a complete measurement chain that integrates quality-controlled biofluid sampling, sensor fusion and metadata capture to convert raw sensor outputs into clinically valid digital biomarkers.
Menstrual blood offers a noninvasive, patient-centric matrix for detecting endometriosis, cervical cancer, and hormonal disorders through self-collected samples. Wearable in-pad biosensors enabling real-time monitoring and long-term tracking could transform fertility evaluation and early disease detection, though standardisation and large-scale validation remain critical gaps.
Shafiq et al., Annals of medicine and surgery · source ↗