Urinary Metabolite Profiling to Non-Invasively Monitor the Omega-3 Index: An Exploratory Secondary Analysis of a Randomized Clinical Trial in Young Adults
MacIntyre et al.
The finding, in our words
In adults given EPA or DHA for 12 weeks, first-void urine analysed by MSI-CE-MS showed increased S-carboxypropylcysteamine and other candidate metabolites that correlated with the Omega-3 Index measured in erythrocytes, suggesting urine could support non-invasive monitoring of omega-3 status.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
The authors developed and validated a chiral GC-MS method to quantify D-amino acid ratios in 1 mL first-void urine samples. In a study of 40 pregnant women, those with gestational diabetes mellitus showed altered urinary D-amino acid profiles compared to controls, suggesting that minimally invasive urine metabolomics could support decentralised screening for pregnancy-related metabolic disorders.
Lorenzo et al., Journal of pharmaceutical and biomedical analysis (paywalled) · source ↗
A panel of four urinary metabolites formate, citrulline, taurine and isocitrate discriminated sugar-sweetened beverage intake with an area under the ROC curve of 0.8 and rose after acute consumption, offering a non-invasive way to assess dietary intake in decentralised settings.
Gibbons et al., The American journal of clinical nutrition (paywalled) · source ↗
DNA methylation markers in first-void urine effectively detect high-grade cervical lesions in HPV-positive women, with results similar to clinician-collected samples in those over 30. This enables reliable cervical cancer screening using self-collected urine, reducing the need for invasive follow-up procedures in decentralised settings.
The study found that testing for ASCL1/LHX8 DNA methylation in at-home collected first-void urine can detect most cervical cancers and high-grade precancers, supporting a fully molecular screening pathway without a clinical visit.
Van Keer et al., Communications medicine · source ↗
A dried urine spot method for measuring 14 amino acids was validated using filter paper and mass spectrometry, offering a stable alternative to liquid urine that supports patient self-collection and remote analysis.
Meikopoulos et al., Talanta (paywalled) · source ↗