Structure-Switching Aptamer-Based Molecular Pendulum for Profiling Melatonin Circadian Dynamics in Humans
Riordan et al.
The finding, in our words
An aptamer-based electrochemical sensor detected melatonin in human interstitial fluid, producing circadian profiles that matched mass spectrometry validation. This structure-switching molecular pendulum approach offers a route to continuous minimally invasive monitoring of hormonal biomarkers.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
Wearable biochemical monitoring requires a complete measurement chain that integrates quality-controlled biofluid sampling, sensor fusion and metadata capture to convert raw sensor outputs into clinically valid digital biomarkers.
Salivary cortisol is suitable as an adjunctive measure in decentralised monitoring, with lateral-flow assays providing rapid low-cost discrete measurements and wearable platforms enabling higher-frequency collection but facing biofouling and calibration challenges. Suitability requires validation in authentic saliva against reference methods, not merely low detection limits.
The review finds that lab-on-chip liquid biopsy technologies are sufficiently mature for distanced cancer screening and follow-up, enabling patient-centric sample collection that reduces exposure risks during pandemics.
Ferrara et al., Biosensors & bioelectronics · source ↗
Saliva is a validated diagnostic matrix for steroids, hormones, therapeutic drugs and drugs of abuse that can be collected non-invasively by patients at home. The review stresses that rigorous collection, handling and storage protocols are critical to prevent false results in decentralised settings.
Boroumand et al., Journal of separation science · source ↗
This review establishes that microsampling across blood, saliva, urine and stool matrices offers validated workflows and regulatory recognition for human biomonitoring comparable to conventional methods. It finds that these decentralised approaches enhance participant acceptability and enable screening in remote or low-resource settings.