2021 · Bioanalysis · paywalled
Kleijne et al.
Dried blood spot hormone measurements can be biased by haematocrit and the review outlines approaches to overcome this bias to ensure accurate results.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
2026
This study found that measuring thyroid-stimulating hormone via dried blood spots and a volumetric device showed high agreement with serum results, with classification accuracy exceeding 96 per cent. The volumetric approach demonstrated improved reproducibility and stability, supporting its use for decentralised thyroid function monitoring.
Bornikowska et al., Practical laboratory medicine · source ↗
2025
This study compared four dried blood spot devices for glucocorticoid detection, finding that the Mitra VAMS device offered the best combination of analytical recovery and user usability, whilst the HemaXis DB10 showed the least bias compared to whole blood.
Chen et al., Analytica chimica acta (paywalled) · source ↗
2025
A 2025 review maps 28 microsampling devices, from dried spots and volumetric absorptive tips to upper-arm liquid capillary collectors, and names what a laboratory must control before their results are used: the haematocrit effect in non-volumetric dried samples, interstitial fluid from finger milking, volume, haemolysis and transport stability. Regulators on both sides of the Atlantic ask for the same two things, a device the patient can use safely and a sample fit for the test.
Spooner et al., Bioanalysis · source ↗
2024
This study found that dried blood spot samples stored at room temperature for four years correlated highly with serum measurements for testosterone and androstenedione, indicating that hematocrit adjustment may be unnecessary for serial monitoring in home-based self-sampling.
Desai et al., The Journal of steroid biochemistry and molecular biology (paywalled) · source ↗
2024
A dried blood spot LC-MS/MS assay for testosterone was validated against venous serum, showing excellent linearity, precision below ten percent, and a lower limit of quantification of 0.086 ng/mL. Haematocrit correction was applied, and the strong clinical correlation supports decentralised hormone monitoring via finger-prick collection.
Gruenstein, Analytical science advances · source ↗