2025 · Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · paywalled
Smartphone-based urine colourimetric assay for home self-screening of HPV infection
Zhang et al.
The finding, in our words
A smartphone based colourimetric assay that detects a metabolic byproduct of HPV infected cells in urine achieved sensitivity and specificity comparable to nucleic acid detection, offering a low cost, user friendly option for home self screening of HPV.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
This study found strong agreement between self-collected urine samples tested with the INDICAID HPV assay and clinician-collected swabs tested with the BD Onclarity assay for detecting high-risk HPV. The results suggest that urine-based self-collection offers a reliable alternative for cervical cancer screening, potentially improving access for women who face barriers to standard care.
Yung et al., Journal of gynecologic oncology (paywalled) · source ↗
In a decentralised Eswatini clinic, molecular testing on the Xpert platform of self-collected urine and swabs found a 31.7% prevalence of Chlamydia, Gonorrhoea, or Trichomonas, with 20.8% of these asymptomatic. Although limited by a cross-sectional design, this shows the feasibility of patient-centric sampling for sexually transmitted infection screening in resource-limited settings.
Kerschberger et al., Tropical medicine & international health : TM & IH · source ↗
This review summarises how emerging HPV detection methods including CRISPR/Cas systems, droplet digital PCR and isothermal amplification, combined with self-collected vaginal swabs and liquid biopsy from urine or blood, could improve screening acceptability and enable point-of-care testing compared with conventional approaches that require invasive sampling and centralised laboratory infrastructure.
Shi et al., Frontiers in cellular and infection microbiology · source ↗
Self-collected vaginal and urine specimens demonstrated good to substantial agreement with clinician-collected cervical samples for detecting high-risk HPV and other sexually transmitted infections, supporting their use in decentralised screening programmes. The higher STI positivity rate among hrHPV-positive women suggests coinfections may influence cervical disease, warranting further investigation.
Giubbi et al., International journal of molecular sciences · source ↗
In 121 women with abnormal cervical cytology, self-collected vaginal samples detected HPV with 77.8% concordance and 75.7% sensitivity compared to clinician-collected cervical samples using the BD Onclarity assay, while spot urine samples stored under optimal conditions (BD Probe Tec container, <72 h at room temperature) achieved only 63.9% concordance and 46.4% sensitivity. This demonstrates that self-collected vaginal sampling is a viable patient-centric approach for decentralised HPV screening, though urine-based testing requires further methodological refinement to improve clinical performance.
Mizuno et al., Gynecologic and obstetric investigation · source ↗