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OpenSampling

2023 · Clinical and translational science · open access

Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling

Liu et al.

The finding, in our words

In 28 healthy adults, alectinib concentrations from capillary microsamples were generally similar to venous ones, which supports the method for therapeutic drug monitoring; the study tested a paediatric-friendly suspension, and the authors point to children, for whom venepuncture is difficult, as the intended use.

A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.

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  1. 2026

    In AML and CLL, 91% of VAMS venetoclax results fell within 20% of plasma after individualised haematocrit correction; in home sampling, 18 of 21 patients self-sampled independently and 76% of returned samples were analysable, which shows home microsampling is workable, though the authors ask for multicentre validation.

    Clinical Validation of Venetoclax Volumetric Microsampling in Leukemia, with Whole-Blood-to-Plasma Conversion and Self-Microsampling FeasibilityLevens et al., Clinical Pharmacokinetics (paywalled) · source ↗

    • vams
    • venous-agreement
    • blood
    • dbs
    • tdm
    • self-collection
    • haematocrit
    • dried
    • oncology
    • capillary
    • validation
  2. 2026

    The True Dose TD-EPI kit demonstrated strong analytical agreement with venous blood for epirubicin monitoring, and the capillary samples remained stable for 72 hours at ambient temperature.

    Method-Comparison Validation of a Novel Capillary Blood Collection Kit, True Dose<sup>®</sup> TD-EPI, for Therapeutic Drug Monitoring of EpirubicinDe Chiara et al., Pharmaceuticals · source ↗

    • venous-agreement
    • stabilised
    • blood
    • tdm
    • oncology
    • capillary
    • liquid
    • validation
  3. 2026

    Fingerstick capillary sampling showed strong agreement with venous sampling for mycophenolic acid, tacrolimus and cyclosporine A, with acceptable bias and improved agreement for mycophenolic acid after haematocrit correction. This minimally invasive approach may reduce procedural burden and support outpatient or home based therapeutic drug monitoring in children.

    Minimally Invasive Therapeutic Drug Monitoring of Immunosuppressants in Children with Kidney Diseases: Validation of Fingerstick Sampling Using LC-MS/MSIshii et al., Pharmaceuticals · source ↗

    • venous-agreement
    • blood
    • tdm
    • haematocrit
    • capillary
    • pediatric
    • immunosuppressants
    • validation
  4. 2026

    This study validated a method requiring only 10 microlitres of serum and found high agreement between fingerstick capillary samples and venous serum for monitoring twelve antibiotics. The results suggest capillary serum sampling is a feasible, minimally invasive alternative that avoids the haematocrit effect associated with whole blood microsampling.

    Feasibility verification of fingerstick capillary microsampling replacing venipuncture for therapeutic drug monitoring of 12 antibiotics using a rapid LC-MS/MS assayChen et al., Talanta (paywalled) · source ↗

    • blood
    • liquid
    • capillary
    • validation
    • venous-agreement
    • pediatric
    • tdm
    • antimicrobials
  5. 2025

    The study found volumetric absorptive microsampling showed high agreement between capillary and venous concentrations, with 94% of dasatinib and 95% of imatinib samples meeting the 20% acceptance criterion. VAMS is viable for imatinib monitoring and may allow longitudinal follow-up for dasatinib; however, VAMS results for imatinib, but not dasatinib, could be converted to plasma concentrations using prior ratios.

    Toward Clinical Implementation of a Volumetric Absorptive Microsampling-Based Method for Dasatinib and Imatinib Therapeutic Drug MonitoringVerougstraete et al., Therapeutic drug monitoring (paywalled) · source ↗

    • blood
    • dried
    • capillary
    • vams
    • validation
    • venous-agreement
    • tdm
    • oncology