Prevalence of HPV infection among Thai schoolgirls in the north-eastern provinces in 2018: implications for HPV immunization policy
Vongpunsawad et al.
The finding, in our words
Urine sampling with the Colli-Pee device revealed a substantial burden of high-risk HPV infection among unvaccinated Thai schoolgirls, with prevalence increasing from 8.6% in grade 10 to 12.4% in grade 12, demonstrating the feasibility of decentralised screening to guide immunisation policy.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
First-void urine samples showed significantly higher detection rates of HPV-specific IgG antibodies compared to midstream urine, confirming the necessity of capturing the initial stream. The study found no significant difference between 10 mL and 20 mL collection volumes, indicating flexibility in device specifications for self-collection.
Van Caesbroeck et al., Human vaccines & immunotherapeutics · source ↗
Over three years after HPV vaccination in 58 women, HPV-specific IgG was detected in 84% to 100% of first-void urine samples against 98% to 100% of serum samples, and the two correlated strongly; the authors support self-collected urine for follow-up of vaccine-induced immunity, with the caveat that only women were studied.
Téblick et al., Journal of medical virology (paywalled) · source ↗
DNA methylation markers in first-void urine effectively detect high-grade cervical lesions in HPV-positive women, with results similar to clinician-collected samples in those over 30. This enables reliable cervical cancer screening using self-collected urine, reducing the need for invasive follow-up procedures in decentralised settings.
Urinary HPV testing using first-void urine collected with the Colli-Pee device showed substantial agreement with clinician-collected cervico-vaginal sampling and near-equivalent negative predictive value, supporting its use as a clinically credible non-invasive entry point for cervical screening in settings where low participation rather than analytical performance is the principal barrier.
Nati et al., Medical sciences (paywalled) · source ↗
This meta-analysis found that self-collected urine samples for HPV testing had lower sensitivity for detecting high-grade lesions compared to physician-collected cervical specimens. The use of a first-void collection device such as Colli-Pee was associated with marginally higher sensitivity than general urine sampling.
Chen et al., Journal of lower genital tract disease (paywalled) · source ↗