Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight
Garcia-Medina et al.
The finding, in our words
Telomere length increased during short-duration spaceflight and shortened after return, while cell-free DNA showed heightened immune signatures persisting for months; dried blood spot microsampling enabled decentralised, patient-centric collection and multi-omic analysis, validating remote specimen collection in extreme environments.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
This review finds that dried microsampling has matured from simple blood spots into diverse devices capable of therapeutic drug monitoring, multiplex biomarker profiling, and multi-omics, with integrated smart sampling and dried immunoassays now ready for field use. The main barriers to clinical translation remain standardisation, automation, and demonstrating full analytical equivalence to venous sampling across protein applications.
Halvorsen et al., Analytical methods : advancing methods and applications (paywalled) · source ↗
Microsampling enables less invasive, patient-centric self-collection of capillary blood for remote monitoring of metabolites and lipids, overcoming conventional venipuncture constraints. Recent device innovations address dried blood spot limitations, particularly haematocrit and volume variations, expanding decentralised applications in population health, drug discovery and multi-omics research.
In a 20-person proof-of-concept pilot among veterans with HIV, remote self-collection of dried blood spots for phosphatidylethanol monitoring was feasible and acceptable, with high return and analysis rates and positive feedback; a small first step toward decentralised alcohol biomarker monitoring rather than proof of it.
Sheinfil et al., Journal of substance use and addiction treatment (paywalled) · source ↗
This review establishes that microsampling across blood, saliva, urine and stool matrices offers validated workflows and regulatory recognition for human biomonitoring comparable to conventional methods. It finds that these decentralised approaches enhance participant acceptability and enable screening in remote or low-resource settings.
A streamlined workflow quantified up to 10,000 protein groups and post-translational modifications from 20 microlitres of dried blood collected by volumetric absorptive microsampling, with mass spectrometry acquisition under two hours. The study established stability profiles and best practices for dried blood proteomics, supporting its feasibility for decentralised precision medicine and disease phenotyping.
Foster et al., Journal of proteome research (paywalled) · source ↗