2022 · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · paywalled
Donor-derived cell-free DNA as a composite marker of acute lung allograft dysfunction in clinical care
Keller et al.
The finding, in our words
Plasma donor-derived cell-free DNA measured at home identified acute lung allograft dysfunction in asymptomatic transplant recipients with 71% sensitivity and 84% specificity, potentially reducing need for surveillance bronchoscopy. This demonstrates decentralised biomarker monitoring can detect rejection and infection early, enabling timely intervention.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
This review summarises how emerging HPV detection methods including CRISPR/Cas systems, droplet digital PCR and isothermal amplification, combined with self-collected vaginal swabs and liquid biopsy from urine or blood, could improve screening acceptability and enable point-of-care testing compared with conventional approaches that require invasive sampling and centralised laboratory infrastructure.
Shi et al., Frontiers in cellular and infection microbiology · source ↗
Urine trans-renal DNA and plasma circulating tumour DNA showed concordant dynamics that paralleled clinical course in a metastatic colorectal cancer patient treated with an ALK inhibitor. Urine-based detection of the CAD-ALK rearrangement anticipated radiological confirmation of disease progression, demonstrating that self-collected urine can non-invasively monitor tumour evolution and emerging resistance mutations during therapy.
Siravegna et al., Annals of oncology : official journal of the European Society for Medical Oncology (paywalled) · source ↗
Self-collected salivary progesterone and the ratio of estradiol to progesterone showed strong agreement with serum levels, supporting the use of saliva as a noninvasive matrix for monitoring the menstrual cycle.
Goldenstein et al., Physiological reports · source ↗
This study validated a lateral flow fluorescence assay using quantum dots for saliva and europium nanoparticles for serum to detect cortisol within physiological ranges. The test operates in 15 minutes with a handheld reader, supporting point-of-care and at-home monitoring without a cold chain.
Bruno et al., Journal of fluorescence (paywalled) · source ↗
A machine learning model called Remote Control was trained on 2685 blood samples to predict change due to instability, enabling accurate calibration of results to approximate the time zero value at collection. With calibration, unprocessed whole blood could be transported for up to 9 days under ambient conditions and temperatures between 3.4 and 47.4 degrees Celsius, achieving agreement with CLIA TEa between 98.1 and 100 per cent and expanding the catalog of tests available for at-home collection.
O'Meara et al., Analytical chemistry (paywalled) · source ↗