Comparison between point-of-care testing from capillary samples and conventional laboratory testing from venous samples for white blood cells and C-reactive protein in a pediatric outpatient setting

Capillary dried blood spots, after haematocrit-dependent conversion, showed good agreement with plasma for 25-hydroxyvitamin D quantification, with 90 per cent of results within 20 per cent of plasma and substantial to almost perfect agreement in status classification, supporting reliable home self-collection for large-scale vitamin D monitoring.

Clinical validation of a DBS-based LC-MS/MS method for 25-hydroxyvitamin D: from lab sampling to home sampling — Heughebaert et al., Clinical chemistry and laboratory medicine (paywalled) · source ↗

• venous-agreement
• blood
• dbs
• self-collection
• haematocrit
• dried
• capillary
• validation
• biomarkers

The study found that capillary dried plasma spots correlated strongly with venous plasma for detecting the Alzheimer's disease biomarker p-tau217. This suggests that microsampling offers a viable, minimally invasive alternative to venipuncture for screening and monitoring Alzheimer's disease pathology.

A minimally invasive dried blood spot biomarker test for the detection of Alzheimer's disease pathology — Huber et al., Nature medicine · source ↗

• blood
• dried
• capillary
• dbs
• venous-agreement
• biomarkers

The homeRNA capillary blood collection and stabilization platform successfully captured lipopolysaccharide-induced inflammatory gene expression profiles. These transcriptomic responses were comparable to those obtained from traditional venous blood samples stabilized with RNAlater or PAXgene, demonstrating the platform's suitability for remote transcriptomic monitoring.

From Home to Transcriptome: Comparing the Transcriptomic Profile of Induced Immune Response via Lipopolysaccharide Stimulation in homeRNA and Venous Blood — Brown et al., Analytical chemistry (paywalled) · source ↗

• venous-agreement
• stabilised
• blood
• capillary
• liquid
• validation
• biomarkers

Self-collected capillary blood samples posted by standard mail showed high concordance with couriered venous samples for HbA1c, creatinine and lipid parameters, supporting their use for remote monitoring in diabetes management and screening.

Concordance of HbA1c, creatinine, LDL cholesterol, HDL cholesterol, and total cholesterol between venous and self-collected capillary blood samples sent by mail — Hoffmeister et al., Journal of diabetes investigation · source ↗

• venous-agreement
• blood
• self-collection
• capillary
• liquid
• validation
• biomarkers

Fingerstick capillary sampling showed strong agreement with venous sampling for mycophenolic acid, tacrolimus and cyclosporine A, with acceptable bias and improved agreement for mycophenolic acid after haematocrit correction. This minimally invasive approach may reduce procedural burden and support outpatient or home based therapeutic drug monitoring in children.

Minimally Invasive Therapeutic Drug Monitoring of Immunosuppressants in Children with Kidney Diseases: Validation of Fingerstick Sampling Using LC-MS/MS — Ishii et al., Pharmaceuticals · source ↗

• venous-agreement
• blood
• tdm
• haematocrit
• capillary
• pediatric
• immunosuppressants
• validation