2023 · British journal of biomedical science · open access
Comparability and Stability of Serum Creatinine Concentration in Capillary and Venous Blood
Woolley et al.
The finding, in our words
Self-collected capillary blood produces serum creatinine results comparable to venous blood, and the analyte remains stable in unspun capillary samples stored at ambient temperature for three days. This supports the use of capillary microsampling for kidney function monitoring in patient-centric, decentralised settings.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
The homeRNA capillary blood collection and stabilization platform successfully captured lipopolysaccharide-induced inflammatory gene expression profiles. These transcriptomic responses were comparable to those obtained from traditional venous blood samples stabilized with RNAlater or PAXgene, demonstrating the platform's suitability for remote transcriptomic monitoring.
Brown et al., Analytical chemistry (paywalled) · source ↗
In pregnant women at high risk of gestational diabetes, the GTT@home capillary glucose device showed a small positive bias of 0.16 mmol/L versus venous laboratory OGTT, with 79.8 per cent of results in the lowest surveillance risk zone and diagnostic classification agreement in 54 of 61 cases, suggesting it could support home OGTT in pregnancy.
The POC haemoglobin device showed moderate correlation with laboratory values but was not accurate enough for routine monitoring; however, it had a high negative predictive value at the 7 g/dL threshold, meaning it can reliably rule out severe anaemia and may help avoid unnecessary transfusions and hospital visits if confirmed in larger studies.
The True Dose TD-EPI kit demonstrated strong analytical agreement with venous blood for epirubicin monitoring, and the capillary samples remained stable for 72 hours at ambient temperature.
This UK consensus opinion outlines how clinical laboratories can validate self-collected capillary blood sampling against venous reference standards to achieve accreditation and facilitate the shift towards community-based patient care.
Woolley et al., Annals of clinical biochemistry (paywalled) · source ↗