Bioanalytical method validation and sample analysis for nirmatrelvir in dried blood collected using the Tasso-M20 device
Wan et al.
The finding, in our words
A bioanalytical method for nirmatrelvir in dried blood collected with the Tasso-M20 device was validated across 20–20,000 ng/ml and showed no haematocrit bias. Stability under various storage conditions was established, and the method performed reliably in clinical studies, supporting decentralised therapeutic drug monitoring of this antiviral.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
The study developed and validated a rapid LC-MS/MS method for quantifying cefazolin in capillary whole blood collected via VAMS, plasma, and plasma ultrafiltrate, showing robust performance across matrices and successful application in a pediatric pilot cohort for therapeutic drug monitoring.
Kocur et al., Clinica chimica acta; international journal of clinical chemistry (paywalled) · source ↗
A UPLC-MS/MS method for linezolid and metabolites in oral fluid and VAMS capillary blood satisfied ICH M10 validation requirements. Linezolid concentrations correlated strongly with venous plasma in both matrices, offering a non‑invasive option for therapeutic drug monitoring, whereas metabolites were systematically underestimated in VAMS and seldom detectable in oral fluid, restricting metabolite measurement.
González-Berdullas et al., Journal of translational medicine (paywalled) · source ↗
The study found that dried blood spot sampling showed good agreement with plasma concentrations for vancomycin and creatinine, with most differences within 20%, and patients preferred the finger prick method over venepuncture, supporting its use for decentralised therapeutic drug monitoring.
Hassanzai et al., The Journal of antimicrobial chemotherapy · source ↗
The authors validated a VAMS method for ivermectin therapeutic drug monitoring in whole blood, achieving a lower limit of quantification of 1 ng/mL and a linear range of 1–150 ng/mL. By eliminating haematocrit effects that limit dried blood spots, the method supports accurate decentralised sampling for antiparasitic therapy.
A validated LC-MS method quantified multiple antibiotics from a single volumetric absorptive microsample, with stability up to 90 days for most analytes and minimal haematocrit effect except vancomycin, enabling pharmacokinetic and pharmacodynamic studies in decentralised settings.
Takyi-Williams et al., Bioanalysis (paywalled) · source ↗