2020 · International journal of psychophysiology : official journal of the International Organization of Psychophysiology · paywalled
Bidirectional relationships between sleep and biomarkers of stress and immunity in youth
LaVoy et al.
The finding, in our words
In youth aged 8–16 years, first-waking saliva cortisol, IL-6 and IL-1β collected at home associate with prior-night actigraphy sleep metrics. Sleep quality confounds interpretation of salivary stress and immune biomarkers in decentralised paediatric microsampling, so protocols must account for it.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
In a 14-day study of youth with neurodevelopmental conditions and chronic pain, multimodal in-home monitoring achieved good accelerometer wear compliance (77% wore devices for at least 7 days) and moderate survey engagement, but adherence to salivary cortisol sampling was low at 28% after excluding protocol violations and dry swabs. Families reported high overall satisfaction and willingness to participate again, highlighting that remote sampling protocols in pediatric populations require iterative tailoring to improve biospecimen collection adherence.
This study found that higher pre-sleep physiological stress, measured via self-collected saliva, was linked to increased cortical arousal during sleep and more consolidated rapid eye movement sleep in adolescents. The results support the use of decentralised sampling and in-home monitoring to investigate physiological interactions in natural sleep environments.
Acutely concussed youth studied at home showed longer sleep latency and greater fatigue than controls, with altered overnight cortisol dynamics and lower bedtime melatonin; these home-based saliva and actigraphy measures highlight decentralised endpoints for acute concussion care.
A US survey of 3,400 adults aged 62 to 90 collected up to 15 biomeasures at home, including saliva, dried blood spots and urine, with Salivette and Oragene among the devices used, which shows that several patient-centric sampling methods can run together in home-based research.
This study used home self-collected saliva samples to successfully monitor cytokines and cortisol in mothers and infants, finding that a community singing intervention significantly reduced salivary interleukin-6 levels in mothers with postnatal depression.