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OpenSampling

2020 · Open forum infectious diseases · open access

Assessing Molecular Point-of-Care Testing and Dried Blood Spot for Hepatitis C Virus Screening in People Who Inject Drugs

Chevaliez et al.

The finding, in our words

Capillary whole-blood point-of-care RNA testing and fingerstick dried blood spot sampling were feasible and acceptable for hepatitis C screening in high-risk individuals at social-medical harm reduction sites. Detection rates were comparable across both methods, enabling simplified screening and successful linkage to pan-genotypic direct-acting antiviral treatment.

A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.

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  1. 2015

    The study validated a commercial ELISA for measuring measles-specific IgG in capillary dried blood spots from children, finding 100% sensitivity and 96.8% specificity against matched venous serum with 92% overall agreement, then applied the method to 1,588 field-collected samples in Mexico and Nicaragua. The procedure was acceptable to surveyors and participants, showing that dried blood spots are a feasible and accurate means of assessing population immunity to measles in low-resource settings.

    Use of a commercial ELISA for the detection of measles-specific immunoglobulin G (IgG) in dried blood spots collected from children living in low-resource settingsColson et al., Journal of medical virology (paywalled) · source ↗

    • blood
    • dried
    • capillary
    • dbs
    • validation
    • venous-agreement
    • acceptability
    • pediatric
    • serology
  2. 2026

    This review found that volumetric microsampling devices, such as Mitra, HemaPEN, HemaXis DB10, and Tasso-M20, overcome haematocrit bias, whilst Telimmune plasma separation cards enable direct plasma collection without centrifugation. These technologies support patient-centric, decentralised sampling, though the authors note that clinical validation remains limited across different drugs and patient populations.

    A Review of Blood-Based Microsampling Devices for Patient-Centered Application in Therapeutic Drug MonitoringHuhn & Scherf-Clavel, Therapeutic drug monitoring (paywalled) · source ↗

    • vams
    • volumetric
    • acceptability
    • neoteryx-mitra
    • blood
    • dbs
    • tdm
    • self-collection
    • haematocrit
    • dried
    • capillary
    • validation
  3. 2026

    The study validated a semi-quantitative protocol for Epstein-Barr virus serology using dried blood spots, demonstrating 98.8% sensitivity and 96.5% specificity compared to paired venous serum samples. The successful validation in a self-sampling cohort confirms the suitability of this patient-centric microsampling approach for large-scale seroprevalence studies and decentralised trials.

    A dried blood spot protocol for high-throughput semi-quantitative analysis of Epstein-Barr Virus VCA IgG and EBNA IgG serologies based on the Roche Elecsys systemRubio-Acero et al., Virology journal · source ↗

    • blood
    • dried
    • capillary
    • dbs
    • self-collection
    • validation
    • venous-agreement
    • serology
  4. 2026

    In a pilot mixed-methods study of youth with HIV, mailed HemaSpot-HF kits enabled home-based dried blood spot collection that participants found feasible and acceptable, supporting remote viral load monitoring and a self-management model for decentralised care.

    An Examination of Perceptions and Usage of Dried Blood Spot Biosampling Technology for HIV Viral Load Collection Among Youth with HIVGurung et al., AIDS and behavior (paywalled) · source ↗

    • blood
    • dried
    • dbs
    • self-collection
    • acceptability
    • dct
    • serology
  5. 2026

    The study found that quantitative dried blood spot sampling provided high clinical agreement for tacrolimus and creatinine monitoring, with patients rating the self-collection devices as user-friendly. These results support the feasibility of decentralised therapeutic drug monitoring for immunosuppressants.

    Patient-centric capillary dried blood spot sampling for tacrolimus and creatinine monitoring in clinical practiceDe Baets et al., Clinical chemistry and laboratory medicine (paywalled) · source ↗

    • blood
    • dried
    • capillary
    • dbs
    • qdbs
    • self-collection
    • venous-agreement
    • acceptability
    • tdm
    • immunosuppressants