Acceptability of dried blood spot collection by primary caregivers of Filipino patients with maple syrup urine disease (MSUD) and phenylketonuria (PKU)

Dried blood spot sampling matched venous serum performance for islet autoantibody detection and was considered minimally invasive and convenient by parents and stakeholders, supporting its use for decentralised screening in home or community settings.

Establishing the performance and acceptability of dried blood spot sampling to screen for islet-specific autoantibodies — Faustini et al., Diabetic medicine : a journal of the British Diabetic Association · source ↗

• blood
• dried
• capillary
• dbs
• self-collection
• validation
• venous-agreement
• acceptability
• pediatric

Adolescents collecting blood microsamples at home achieved varying success rates across six devices, with Minicollect tubes performing poorest. The confirmation that visual inspection alone was insufficient, by analytical variability, underscores the need for robust quality assessment before deploying any device in decentralised trials.

Self-Sampling by Adolescents at Home: Assessment of the Feasibility to Successfully Collect Blood Microsamples by Inexperienced Individuals — Boffel et al., The AAPS journal (paywalled) · source ↗

• blood
• liquid
• dried
• capillary
• vams
• dbs
• neoteryx-mitra
• self-collection
• acceptability
• pediatric
• dct

VAMS microsampling found no significant difference from venous blood for tacrolimus in paediatric patients; samples were stable for 14 days, with average difference between paired at-home samples of 0.12 ± 0.94 ng/mL.

VAMS and parallel-reaction-monitoring mass spectrometry for tacrolimus trough measurements at home in paediatric heart-transplant patients — Zhao et al., J. Mass Spectrometry and Advances in the Clinical Lab · source ↗

• vams
• venous-agreement
• acceptability
• blood
• dbs
• tdm
• self-collection
• dried
• capillary
• pediatric
• immunosuppressants
• validation

Self-collection of dried blood spots in the home was feasible for healthy youth, with 82% consenting to provide a sample in the lab and 75% of those willing to self-collect at home, and DNA extraction quality was high across demographic groups.

At-home dried blood spot (DBS) collection to increase population heterogeneity representation in pediatric research: An ECHO study — Green et al., Frontiers in pediatrics · source ↗

• acceptability
• blood
• dbs
• self-collection
• dried
• pediatric
• genotyping

In a Ugandan cohort, 96% of participants successfully collected at least 16 of 24 requested at-home dried blood spots, with strong correlation (R=0.93) between parasite RNA detected in self-collected spots and venous blood. The method was well tolerated, indicating self-collected DBS can reliably support decentralised malaria surveillance in endemic settings.

Feasibility of community at-home dried blood spot collection combined with pooled reverse transcription PCR as a viable and convenient method for malaria epidemiology studies — Hergott et al., Malaria journal · source ↗

• blood
• dried
• dbs
• self-collection
• venous-agreement
• acceptability
• pediatric
• serology