2021 · Journal of pharmaceutical and biomedical analysis · paywalled
A validated surrogate analyte LC-MS/MS assay for quantification of endogenous cortisol in human whole blood
Agrawal et al.
The finding, in our words
A surrogate-analyte LC-MS/MS method for cortisol in whole blood was validated, showing linearity from 0.5 to 500 ng/mL with acceptable accuracy and precision per regulatory guidance. Evaluation of patient samples demonstrated comparable cortisol concentrations in whole blood and plasma, indicating that whole blood sampling could support patient-centric, at-home collection in decentralised trials and clinical diagnostics.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
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