2015 · Journal of pharmaceutical and biomedical analysis · paywalled
A validated method for the quantification of fosfomycin on dried plasma spots by HPLC-MS/MS: application to a pilot pharmacokinetic study in humans
Parker et al.
The finding, in our words
The LC-MS/MS method quantified fosfomycin in dried plasma spots with linearity from 5 to 2000 mg/L, good precision and accuracy, 83.6% recovery, and stability at room temperature for three months and at 50°C for four hours; Bland-Altman comparison to venous plasma showed a negative bias of 16.6% with most values within agreement limits, indicating DPS is useful for pharmacokinetic studies but may require calibration adjustment.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
A UPLC-MS/MS method for linezolid and metabolites in oral fluid and VAMS capillary blood satisfied ICH M10 validation requirements. Linezolid concentrations correlated strongly with venous plasma in both matrices, offering a non‑invasive option for therapeutic drug monitoring, whereas metabolites were systematically underestimated in VAMS and seldom detectable in oral fluid, restricting metabolite measurement.
González-Berdullas et al., Journal of translational medicine (paywalled) · source ↗
The study found that dried blood spot sampling showed good agreement with plasma concentrations for vancomycin and creatinine, with most differences within 20%, and patients preferred the finger prick method over venepuncture, supporting its use for decentralised therapeutic drug monitoring.
Hassanzai et al., The Journal of antimicrobial chemotherapy · source ↗
VAMS finger-prick sampling showed moderate agreement with conventional venous sampling for clofazimine, with a systematic 13% lower concentration that can be corrected, and was more cost-effective by about 4.45 USD per sample, supporting its use for routine therapeutic drug monitoring in MDR-TB.
Nugraha et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled) · source ↗
Volumetric absorptive microsampling of whole blood did not provide a reliable basis for calculating meropenem plasma concentrations in critically ill children, so a validated low volume plasma method was required for paediatric therapeutic drug monitoring.
Ramadan et al., Therapeutic drug monitoring (paywalled) · source ↗
The validated LC-MS/MS method showed similar pharmacokinetic profiles for albendazole and its metabolites across plasma, whole blood, dried blood spots and Mitra microsamples from hookworm-infected adolescents, supporting microsampling for paediatric pharmacokinetic studies. Mitra extraction proved more robust than dried blood spots during validation and is recommended for future albendazole pharmacokinetic work, despite higher albendazole sulfone concentrations observed in both microsampling devices compared with wet matrices.
Schulz et al., Antimicrobial agents and chemotherapy (paywalled) · source ↗