Validation of a microsampling-compatible liquid-liquid extraction method for cannabinoid quantitation in 50 µL of whole blood using liquid chromatography-mass spectrometry

The analysis indicates that dried blood spots and volumetric absorptive microsampling enable minimally invasive monitoring of prohibited substances, with volumetric absorptive microsampling offering improved quantitative reliability over traditional dried spots.

Liquid Chromatographic Methods for Microsampling in Sports Drug Monitoring: Progress in DBS and VAMS — Zhang, Biomedical chromatography : BMC (paywalled) · source ↗

• vams
• doping
• blood
• dbs
• dried
• steroids
• toxicology
• hormones
• validation
• biomarkers

VAMS gave near‑quantitative recovery for cadmium and lead in human blood and correlated strongly with venous sampling, with pre‑cleaning improving correlation and lowering background lead, supporting its use for decentralised biomonitoring of these toxic elements.

Application of volumetric absorptive microsampling (VAMS) for the simultaneous determination of cadmium and lead in blood — Gutknecht et al., Environmental monitoring and assessment (paywalled) · source ↗

• vams
• venous-agreement
• blood
• dried
• toxicology
• validation

This study validated a lateral flow fluorescence assay using quantum dots for saliva and europium nanoparticles for serum to detect cortisol within physiological ranges. The test operates in 15 minutes with a handheld reader, supporting point-of-care and at-home monitoring without a cold chain.

Ultrasensitive de novo Protein Sandwich Lateral flow Fluorescence Assay for Cortisol in Saliva and Serum using Quantum dots and Europium Nanoparticles — Bruno et al., Journal of fluorescence (paywalled) · source ↗

• blood
• saliva
• liquid
• self-collection
• validation
• hormones
• cortisol

The homeRNA capillary blood collection and stabilization platform successfully captured lipopolysaccharide-induced inflammatory gene expression profiles. These transcriptomic responses were comparable to those obtained from traditional venous blood samples stabilized with RNAlater or PAXgene, demonstrating the platform's suitability for remote transcriptomic monitoring.

From Home to Transcriptome: Comparing the Transcriptomic Profile of Induced Immune Response via Lipopolysaccharide Stimulation in homeRNA and Venous Blood — Brown et al., Analytical chemistry (paywalled) · source ↗

• venous-agreement
• stabilised
• blood
• capillary
• liquid
• validation
• biomarkers

In pregnant women at high risk of gestational diabetes, the GTT@home capillary glucose device showed a small positive bias of 0.16 mmol/L versus venous laboratory OGTT, with 79.8 per cent of results in the lowest surveillance risk zone and diagnostic classification agreement in 54 of 61 cases, suggesting it could support home OGTT in pregnancy.

Use of the GTT@home Oral Glucose Tolerance Test Kit in Gestational Diabetes Mellitus: Performance Evaluation Study — Dunseath et al., JMIR diabetes · source ↗

• blood
• liquid
• capillary
• validation
• venous-agreement