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OpenSampling

2017 · Anticancer research · paywalled

Vaginal and Urine Self-sampling Compared to Cervical Sampling for HPV-testing with the Cobas 4800 HPV Test

Asciutto et al.

The finding, in our words

The Cobas 4800 HPV test detected high-grade pre-cancerous cervical lesions in self-collected vaginal samples with the same sensitivity as clinician-taken cervical samples at 92.8 per cent, while urine self-sampling achieved a lower sensitivity of 76.3 per cent, supporting vaginal self-sampling as a viable decentralised alternative to clinic-based cervical screening.

A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.

Read the source ↗DOI 10.21873/anticanres.11807PubMed 28739704

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Papers that share these labels

  1. 2026

    This meta-analysis found that HPV testing using self-collected vaginal and urine samples showed sensitivities of 88.6% and 81% for detecting cervical precancer. Using a standardised device for first-void urine increased sensitivity to 86.6%, supporting decentralised patient-centric screening, though data on specificity and specific commercial devices were not consistently reported.

    Diagnostic Performance of HPV Testing Using Self-Collected Urine and Vaginal Samples for Detecting Cervical Precancer or Worse: A Meta-Analysis — Hsiao et al., The journal of obstetrics and gynaecology research (paywalled) · source ↗

    • urine
    • first-void
    • self-collection
    • validation
    • hpv
    • sti

  2. 2026

    This meta-analysis found that self-collected urine samples for HPV testing had lower sensitivity for detecting high-grade lesions compared to physician-collected cervical specimens. The use of a first-void collection device such as Colli-Pee was associated with marginally higher sensitivity than general urine sampling.

    Accuracy of HPV Testing Using Self-collected Urine Compared With Physician-collected Cervical Specimen for HSIL or Worse — Chen et al., Journal of lower genital tract disease (paywalled) · source ↗

    • urine
    • first-void
    • colli-pee
    • self-collection
    • validation
    • hpv
    • sti

  3. 2026

    Vaginal self-sampling achieved higher pooled sensitivity and specificity than urine self-sampling for detecting high-risk HPV, making it the preferred option, while urine self-sampling remains a useful non-invasive choice for under-screened populations.

    Diagnostic Accuracy of Urine and Vaginal Self-Sampling for Detection of High-Risk Human Papillomavirus: A Systematic Review and Meta-Analysis — Rakhat & Aimagambetova, Viruses · source ↗

    • first-void
    • sti
    • self-collection
    • hpv
    • urine
    • validation

  4. 2026

    For decentralised testing, a study found dry vaginal self-samples using Copan FLOQSwabs stored up to two weeks at room temperature maintain DNA quality. However, first-void urine collected with the Colli-Pee device may be less sensitive for HPV detection, showing lower positivity and higher cycle threshold values, median Ct 30 versus 27 for other samples.

    Evaluation of the Quality and Suitability of Self-Collected Vaginal and Urine Samples for Human Papillomavirus Testing: A Prospective Matched Study — Chu et al., BJOG : an international journal of obstetrics and gynaecology · source ↗

    • colli-pee
    • first-void
    • sti
    • self-collection
    • dried
    • hpv
    • urine
    • validation

  5. 2026

    Self-sampling for HPV testing using urine and swab devices achieved high DNA detection rates, 92.1-99.7%, and very high participant acceptance, 99.1%, in a primary care population, supporting decentralised screening in low-resource settings.

    Population-based self-sampling under primary care conditions - a possible approach for cervical cancer screening in Indonesia (IndoCerCa study) — Wenang et al., Reproductive health · source ↗

    • urine
    • self-collection
    • validation
    • acceptability
    • hpv
    • sti