Tip-Enhanced Sub-Femtomolar Steroid Immunosensing via Micropyramidal Flexible Conducting Polymer Electrodes for At-Home Monitoring of Salivary Sex Hormones

This study used home self-collected saliva samples to successfully monitor cytokines and cortisol in mothers and infants, finding that a community singing intervention significantly reduced salivary interleukin-6 levels in mothers with postnatal depression.

Community singing intervention reduces maternal salivary cytokines and enhances maternal-infant cortisol synchrony in postnatal depression: biological findings from the SHAPER-PND trial — Kirkpatrick et al., Brain, behavior, and immunity (paywalled) · source ↗

• dct
• cortisol
• self-collection
• pediatric
• hormones
• liquid
• saliva
• biomarkers

At-home saliva sampling for cortisol was feasible over 12 days in two people with poststroke aphasia, with the cortisol awakening response remaining consistent across days and weeks.

Intraindividual Variability of the Cortisol Awakening Response, Sleep Dynamics, Stress, and Emotion in Two Persons With Poststroke Aphasia — Laures-Gore et al., Journal of speech, language, and hearing research : JSLHR (paywalled) · source ↗

• cortisol
• self-collection
• hormones
• liquid
• saliva

Self-collected salivary progesterone and the ratio of estradiol to progesterone showed strong agreement with serum levels, supporting the use of saliva as a noninvasive matrix for monitoring the menstrual cycle.

Salivary estradiol and progesterone across the menstrual cycle: Association and agreement with serum concentrations — Goldenstein et al., Physiological reports · source ↗

• venous-agreement
• blood
• self-collection
• fertility
• hormones
• saliva

This study found that salivary 11-dehydrodexamethasone correlates strongly with serum dexamethasone, unlike salivary dexamethasone which shows poor agreement. This validation suggests patients could self-collect saliva samples at home to verify dexamethasone absorption for the overnight suppression test.

The Utility of Salivary 11-Dehydrodexamethasone as a Marker of Dexamethasone Absorption — Marshall et al., The Journal of clinical endocrinology and metabolism (paywalled) · source ↗

• venous-agreement
• tdm
• cortisol
• self-collection
• hormones
• liquid
• validation
• saliva

This study validated a lateral flow fluorescence assay using quantum dots for saliva and europium nanoparticles for serum to detect cortisol within physiological ranges. The test operates in 15 minutes with a handheld reader, supporting point-of-care and at-home monitoring without a cold chain.

Ultrasensitive de novo Protein Sandwich Lateral flow Fluorescence Assay for Cortisol in Saliva and Serum using Quantum dots and Europium Nanoparticles — Bruno et al., Journal of fluorescence (paywalled) · source ↗

• blood
• saliva
• liquid
• self-collection
• validation
• hormones
• cortisol