Saliva-derived transcriptomic signature for gastric cancer detection using machine learning and leveraging publicly available datasets

This study used home self-collected saliva samples to successfully monitor cytokines and cortisol in mothers and infants, finding that a community singing intervention significantly reduced salivary interleukin-6 levels in mothers with postnatal depression.

Community singing intervention reduces maternal salivary cytokines and enhances maternal-infant cortisol synchrony in postnatal depression: biological findings from the SHAPER-PND trial — Kirkpatrick et al., Brain, behavior, and immunity (paywalled) · source ↗

• dct
• cortisol
• self-collection
• pediatric
• hormones
• liquid
• saliva
• biomarkers

In people at high risk of nasopharyngeal carcinoma, saliva showed decreased EBV load and increased EBV DNA methylation compared with controls, and a stepwise strategy that adds saliva testing to serum EBV antibodies improved triage efficiency.

Evaluation of Epstein-Barr virus DNA methylation and load in saliva in the management of individuals at high risk of nasopharyngeal carcinoma — Zheng et al., Biomarker research · source ↗

• serology
• liquid-biopsy
• liquid
• saliva
• biomarkers

Salivary HPV DNA testing achieved 91.7% sensitivity and 100% specificity against oropharyngeal swab in patients with oral cavity cancer, demonstrating potential for non-invasive self-collection screening programmes and long-term monitoring of HPV-driven disease.

Application of a Saliva-Based Liquid Biopsy for the Detection of HPV in Patients With Oral Cavity Squamous Cell Carcinoma (OCSCC) — Bulfoni et al., Head & neck · source ↗

• self-collection
• hpv
• liquid-biopsy
• liquid
• validation
• saliva

This paper describes a handheld electrochemical sensor for vitamin C measurement in saliva and urine, showing a linear range from 0.2 to 200 µm and detection limit of 0.03 µm. The device demonstrated satisfactory accuracy and recovery in human samples, suggesting potential for affordable home-based testing of vitamin C status.

A Multi-Channel Handheld Diagnostic Device Based on Green Biomimetic Material for Point-of-Care Testing of Vitamin C in Human Fluids — Fu et al., Advanced healthcare materials (paywalled) · source ↗

• saliva
• urine
• liquid
• self-collection
• biomarkers

A coffee-ring biosensor detected sepsis, COVID-19 and cancer proteins from self-collected saliva down to 3 pg/ml within 12 minutes, achieving sensitivity more than 100-fold higher than lateral flow assays. The system uses a smartphone camera and AI analysis, providing a rapid, affordable platform for decentralised protein diagnostics.

Plasmonic coffee-ring biosensing for AI-assisted point-of-care diagnostics — Behrouzi et al., Nature communications · source ↗

• self-collection
• serology
• liquid
• saliva
• biomarkers