Relationship between Chlamydia trachomatis and Mycoplasma genitalium infection and pregnancy rate and outcome in Iranian infertile couples
Dehghan Marvast et al.
The finding, in our words
In 250 Iranian infertile couples followed for 24 months, detection of Chlamydia trachomatis DNA in first-void urine, semen or serum antibodies did not predict tubal factor infertility, pregnancy rate or outcome. This indicates that patient-collected first-void urine screening for these organisms may have limited clinical utility in fertility assessment.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
The study found comparable seropositivity for Chlamydia trachomatis and Toxoplasma gondii among male partners of infertile couples in Odisha, with 28 per cent showing anti-Chlamydia IgA and 28 per cent anti-Toxoplasma IgM antibodies. This demonstrates that first-void urine and seminal fluid can detect relevant infections, supporting their use in decentralised fertility screening programmes.
Naik et al., The Indian journal of medical research · source ↗
Among 250 infertile Iranian men, self-collected first-void urine enabled decentralised detection of Chlamydia trachomatis, yet infection status showed no correlation with sperm chromatin condensation or DNA fragmentation. The study validates first-void urine for remote STI screening in fertility assessment, while indicating sperm quality markers are independent of Chlamydia infection.
Dehghan Marvast et al., Andrologia (paywalled) · source ↗
The study of 250 infertile men found that Chlamydia trachomatis infection detected in first-void urine by PCR was associated with lower semen volume, while seminal interleukin levels showed non-significant elevation. This supports the use of patient-centric first-void urine and blood samples for screening sexually transmitted infections in decentralised fertility diagnostics.
Dehghan Marvast et al., Andrologia (paywalled) · source ↗
A cross-sectional survey of 1,087 men who have sex with men in Jiangsu province, China found a syphilis prevalence of 6.3% and chlamydia prevalence of 4.2%, with higher odds among those recruited online and with recent STI diagnosis. The use of first-void urine for nucleic acid amplification testing demonstrates the utility of decentralised sampling for STI screening in high-risk populations.
In a Toronto clinic sample of 442 men who have sex with men, HIV‑positive individuals showed significantly higher prevalences of syphilis, hepatitis B and C, HSV‑2, CMV and high‑risk anal HPV than HIV‑negative men, while chlamydia and gonorrhoea were uncommon. The use of blood serology, urine and self‑collected anal swabs enabled comprehensive STI surveillance, supporting routine screening in this high‑risk population.