Pilot phase clinical trial of a wearable, electrochemical aptamer-based patch for continuous drug concentration measurement
Booth et al.
The finding, in our words
A wearable electrochemical aptamer patch was safe and virtually painless in six healthy participants and captured continuous vancomycin concentrations in dermal interstitial fluid with 5‑minute resolution over 12 hours, revealing distribution and clearance dynamics not detected with sparse sampling; with further development this could support precision dosing of vancomycin and other drugs with narrow therapeutic windows.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
A microneedle wearable biosensor continuously measured levodopa in interstitial fluid of Parkinson's patients and healthy volunteers, showing a 9.64% mean absolute relative difference against plasma HPLC measurements after calibration. The temporal drug profiles inversely correlated with motor performance, demonstrating potential for real-time therapeutic drug monitoring to guide dosing without repeated venous sampling.
Reynoso et al., ACS sensors (paywalled) · source ↗
A fully remote decentralised clinical trial in Danish adults with type 2 diabetes demonstrated operational feasibility with rapid recruitment, high retention (87 percent), and excellent adherence to continuous glucose monitoring (95 percent achieving ≥70 percent data coverage) and telemedicine visits (97 percent). Activity tracker adherence was poor (12 percent) due to technical issues, but remote safety monitoring was effective with no unexpected adverse events, supporting the viability of remote diabetes management.
In adults with type 1 diabetes, Dexcom G7 and FreeStyle Libre 3 showed high accuracy during physical activity, whereas the Simplera system was less accurate; this matters for selecting devices in decentralised monitoring.
Sanfilippo et al., Diabetes, obesity & metabolism · source ↗
In adults with MASLD, sucrose-free brazzein-sweetened ice cream produced smaller postprandial glucose excursions and lower incremental area under the curve over 150 min than sucrose-sweetened ice cream, measured by continuous glucose monitoring.
Isakov et al., Clinical nutrition ESPEN (paywalled) · source ↗
Wearable biochemical monitoring requires a complete measurement chain that integrates quality-controlled biofluid sampling, sensor fusion and metadata capture to convert raw sensor outputs into clinically valid digital biomarkers.