2026 · Diabetes, obesity & metabolism · open access
Performance of three simultaneously used rtCGM systems around a physically active weekend camp in adults with type 1 diabetes: A prospective lab and real-world study
Sanfilippo et al.
The finding, in our words
In adults with type 1 diabetes, Dexcom G7 and FreeStyle Libre 3 showed high accuracy during physical activity, whereas the Simplera system was less accurate; this matters for selecting devices in decentralised monitoring.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
In a head-to-head study of 24 adults with type 1 diabetes, the Dexcom G4 Platinum sensor had a lower overall MARD than the Medtronic Enlite sensor (13.6% vs 16.6% in the clinical research centre and 13.8% vs 17.9% overall), with both devices showing reduced accuracy in the hypoglycaemic range and the Dexcom sensor less affected by this impairment.
Kropff et al., Diabetes, obesity & metabolism · source ↗
A fully remote decentralised clinical trial in Danish adults with type 2 diabetes demonstrated operational feasibility with rapid recruitment, high retention (87 percent), and excellent adherence to continuous glucose monitoring (95 percent achieving ≥70 percent data coverage) and telemedicine visits (97 percent). Activity tracker adherence was poor (12 percent) due to technical issues, but remote safety monitoring was effective with no unexpected adverse events, supporting the viability of remote diabetes management.
In adults with MASLD, sucrose-free brazzein-sweetened ice cream produced smaller postprandial glucose excursions and lower incremental area under the curve over 150 min than sucrose-sweetened ice cream, measured by continuous glucose monitoring.
Isakov et al., Clinical nutrition ESPEN (paywalled) · source ↗
In a Phase 1 crossover study of etrasimod, self-collected blood microsamples yielded pharmacokinetic exposures comparable to conventional venous sampling, both with and without participant practice sessions. Continuous wearable sensors concurrently enabled real-time remote monitoring of safety vital signs and electrocardiograms, demonstrating the viability of hybrid decentralised designs in early-phase clinical trials.
Malhotra et al., Clinical pharmacology and therapeutics · source ↗
The study demonstrates that frequent collection of 10 microlitres of capillary blood, combined with wearable sensor data, enables simultaneous measurement of thousands of metabolites, lipids, cytokines and proteins, revealing individualised metabolic and inflammatory responses to dietary interventions and molecular fluctuations linked to intra-day changes in heart rate, glucose, cortisol and physical activity, supporting dynamic health profiling outside the clinic.
Shen et al., Nature biomedical engineering · source ↗