Evaluation of Tetrahydrobiopterin Therapy with Large Neutral Amino Acid Supplementation in Phenylketonuria: Effects on Potential Peripheral Biomarkers, Melatonin and Dopamine, for Brain Monoamine Neurotransmitters

In healthy women, first-void urinary and plasma green tea catechins correlated weakly to moderately with lipid profiles and glycated haemoglobin. This supports the utility of non-invasive first-void urine collection for evaluating dietary and cardiometabolic biomarkers in decentralized studies.

Elevated plasma and urinary concentrations of green tea catechins associated with improved plasma lipid profile in healthy Japanese women — Takechi et al., Nutrition research (paywalled) · source ↗

• blood
• urine
• first-void
• biomarkers

A US survey of 3,400 adults aged 62 to 90 collected up to 15 biomeasures at home, including saliva, dried blood spots and urine, with Salivette and Oragene among the devices used, which shows that several patient-centric sampling methods can run together in home-based research.

Continuity and innovation in the data collection protocols of the second Wave of the National Social Life, Health, and Aging Project — Jaszczak et al., The journals of gerontology. Series B, Psychological sciences and social sciences (paywalled) · source ↗

• actigraphy
• multimodal
• blood
• dbs
• cortisol
• dna-genotek-oragene
• self-collection
• dried
• bd-microtainer
• hormones
• liquid
• urine
• saliva
• biomarkers
• genotyping

Higher vegetable and carbohydrate intake was associated with a lower urinary estrogen DNA adduct ratio in healthy pre‑menopausal women, suggesting dietary factors may modulate a biomarker linked to breast cancer risk.

Associations between Dietary Intake of Fruits and Vegetables in relation to Urinary Estrogen DNA Adduct Ratio — Reding et al., Open journal of preventive medicine (paywalled) · source ↗

• first-void
• hormones
• urine
• biomarkers

In a cross-over study of adults with phenylketonuria, adding tryptophan and tyrosine to large neutral amino acid therapy increased urine dopamine but not melatonin metabolite levels, indicating serotonin synthesis remains suppressed by phenylalanine. The protocol demonstrates first-void urine sampling can support therapeutic drug monitoring for metabolic disorders.

Melatonin and dopamine as biomarkers to optimize treatment in phenylketonuria: effects of tryptophan and tyrosine supplementation — Yano et al., The Journal of pediatrics (paywalled) · source ↗

• first-void
• tdm
• hormones
• urine
• biomarkers

DNA methylation markers in first-void urine effectively detect high-grade cervical lesions in HPV-positive women, with results similar to clinician-collected samples in those over 30. This enables reliable cervical cancer screening using self-collected urine, reducing the need for invasive follow-up procedures in decentralised settings.

Evaluating DNA methylation markers and extended HPV genotyping in first-void urine for detecting high-grade cervical lesions in HPV-positive women: a cross-sectional study — Tranberg et al., BMC medicine · source ↗

• colli-pee
• first-void
• self-collection
• hpv
• urine
• biomarkers
• genotyping