Evaluation of Tetrahydrobiopterin Therapy with Large Neutral Amino Acid Supplementation in Phenylketonuria: Effects on Potential Peripheral Biomarkers, Melatonin and Dopamine, for Brain Monoamine Neurotransmitters
Yano et al.
The finding, in our words
Blood phenylalanine concentrations affected peripheral neurotransmitter biomarker concentrations differently in each of nine adults with phenylketonuria. Melatonin increased with tetrahydrobiopterin therapy only when blood phenylalanine fell, indicating that monitoring metabolites in first‑void urine and blood could help optimise individualised treatment.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
In healthy women, first-void urinary and plasma green tea catechins correlated weakly to moderately with lipid profiles and glycated haemoglobin. This supports the utility of non-invasive first-void urine collection for evaluating dietary and cardiometabolic biomarkers in decentralized studies.
Takechi et al., Nutrition research (paywalled) · source ↗
A US survey of 3,400 adults aged 62 to 90 collected up to 15 biomeasures at home, including saliva, dried blood spots and urine, with Salivette and Oragene among the devices used, which shows that several patient-centric sampling methods can run together in home-based research.
Jaszczak et al., The journals of gerontology. Series B, Psychological sciences and social sciences (paywalled) · source ↗
Higher vegetable and carbohydrate intake was associated with a lower urinary estrogen DNA adduct ratio in healthy pre‑menopausal women, suggesting dietary factors may modulate a biomarker linked to breast cancer risk.
Reding et al., Open journal of preventive medicine (paywalled) · source ↗
In a cross-over study of adults with phenylketonuria, adding tryptophan and tyrosine to large neutral amino acid therapy increased urine dopamine but not melatonin metabolite levels, indicating serotonin synthesis remains suppressed by phenylalanine. The protocol demonstrates first-void urine sampling can support therapeutic drug monitoring for metabolic disorders.
Yano et al., The Journal of pediatrics (paywalled) · source ↗
DNA methylation markers in first-void urine effectively detect high-grade cervical lesions in HPV-positive women, with results similar to clinician-collected samples in those over 30. This enables reliable cervical cancer screening using self-collected urine, reducing the need for invasive follow-up procedures in decentralised settings.