Efficacy and role of Xpert^® <i>Mycobacterium tuberculosis</i>/rifampicin assay in urinary tuberculosis

First-void urine samples showed significantly higher detection rates of HPV-specific IgG antibodies compared to midstream urine, confirming the necessity of capturing the initial stream. The study found no significant difference between 10 mL and 20 mL collection volumes, indicating flexibility in device specifications for self-collection.

The importance of first-void urine for assessing HPV-specific antibodies: A comparison with midstream urine — Van Caesbroeck et al., Human vaccines & immunotherapeutics · source ↗

• first-void
• sti
• self-collection
• serology
• hpv
• urine

First-void urine sampling detected 33% prevalence of 28 HPV types in 16-21-year-old Ugandan females. HPV16/18 prevalence was markedly lower among vaccinated participants (1.4%) than unvaccinated (5.6%), though vaccine coverage was suboptimal with inconsistent dosing. This validates patient-centric urine microsampling for decentralised infectious disease surveillance in resource-limited settings.

Human papillomavirus infection and vaccination among young females in rural Uganda — Newton et al., International journal of cancer (paywalled) · source ↗

• urine
• first-void
• serology
• hpv

First-void urine PCR identified Ureaplasma urealyticum in 19% of symptomatic men, alongside other pathogens, confirming that patient-collected urine samples provide valid diagnostic results for STI screening outside traditional clinical settings.

Investigation of mycoplasma and ureaplasma species using a molecular method in male patients suffering from urethritis symptoms: a cross-sectional study in the city of Antalya — Karpuz et al., BMC urology · source ↗

• first-void
• sti
• serology
• urine

Four years after vaccination, HPV-16/18 prevalence in schoolgirls fell from 3–6% to under 0.6% for both single-dose and two-dose regimens, with single-dose effectiveness at 90.6% proving non-inferior to the two-dose schedule. This validates first-void urine sampling for community-based vaccine effectiveness monitoring in decentralised screening programmes.

Community intervention of a single-dose or 2-dose regimen of bivalent human papillomavirus vaccine in schoolgirls in Thailand: vaccine effectiveness 2 years and 4 years after vaccination — Jiamsiri et al., Journal of the National Cancer Institute. Monographs · source ↗

• first-void
• serology
• hpv
• pediatric
• urine

A time-resolved fluorescence assay detected HPV16-specific IgG in first-void urine with strong correlation to paired serum across four immunoassays in 225 healthy women, supporting first-void urine as a non-invasive alternative to venous blood for HPV antibody monitoring.

Time-resolved fluorescence (TRF) for total IgG and HPV16-specific antibody detection in first-void urine and serum: A comparative study — Lipovac et al., Journal of virological methods · source ↗

• urine
• first-void
• validation
• venous-agreement
• serology
• hpv