2020 · Nutrition research and practice · open access
Development of objective indicators for quantitative analysis of sodium intake: the sodium to potassium ratio of second-void urine is correlated with 24-hour urinary sodium excretion
Kim et al.
The finding, in our words
In fifteen men consuming a controlled salt intake, second-void urine provided more reliable estimates of 24-hour urinary sodium excretion than first-void urine, with the sodium-to-potassium ratio in first-day second-void samples showing significant correlation with measured 24-hour output. This suggests spot second-void sampling could replace cumbersome 24-hour collections for sodium intake assessment in decentralised nutrition monitoring.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
Adding polyethylene glycol to first-void urine before centrifugation markedly improved cell-free DNA recovery in the pellet, whereas low-speed centrifugation alone removed cellular DNA while keeping cell-free DNA in the supernatant. Pseudovirions pelleted reliably under all conditions, but the study revealed substantial variation between self-collected samples, highlighting the need for standardised protocols in decentralised HPV screening programmes.
Téblick et al., European journal of medical research · source ↗
The review concludes that first-void urine is a feasible source for molecular biomarkers, such as host and viral gene methylation, to triage high-risk HPV infections, offering a non-invasive and preferred method for women that may improve screening adherence.
Van Keer et al., European journal of obstetrics, gynecology, and reproductive biology (paywalled) · source ↗
The study standardises leukocyte and interleukin-6 measurements in first-void urine, expressed prostatic secretion and post-massage urine from 541 adults and defines ROC-based cut-offs to distinguish inflammatory from non-inflammatory prostate disease, enabling more precise treatment selection in decentralised settings.
Korrovits et al., Andrology (paywalled) · source ↗
The authors developed and validated a chiral GC-MS method to quantify D-amino acid ratios in 1 mL first-void urine samples. In a study of 40 pregnant women, those with gestational diabetes mellitus showed altered urinary D-amino acid profiles compared to controls, suggesting that minimally invasive urine metabolomics could support decentralised screening for pregnancy-related metabolic disorders.
Lorenzo et al., Journal of pharmaceutical and biomedical analysis (paywalled) · source ↗
This meta-analysis found that HPV testing using self-collected vaginal and urine samples showed sensitivities of 88.6% and 81% for detecting cervical precancer. Using a standardised device for first-void urine increased sensitivity to 86.6%, supporting decentralised patient-centric screening, though data on specificity and specific commercial devices were not consistently reported.
Hsiao et al., The journal of obstetrics and gynaecology research (paywalled) · source ↗