Collecting at-Home Biometric Measures for Longitudinal Research From the i3C: Feasibility and Acceptability Study
Russell et al.
The finding, in our words
In a one-week virtual home clinic with 134 participants, 86 per cent returned saliva and 84 per cent returned stool, and most components were feasible and acceptable despite device and logistical challenges. This supports decentralised, patient-centric self-collection of non-blood biospecimens for research.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
This study demonstrated that a fully remote genome sequencing study using self-collected dried blood spots and buccal swabs is feasible for individuals with Prader-Willi syndrome, with all participants completing the study and reporting the process was easy despite being lengthy. The design successfully returned actionable genetic findings, including those related to blood clot formation, to participants.
Vrana-Diaz et al., Genetics in medicine open · source ↗
In a cross-sectional study of 90 adolescents, 94 per cent provided at least one salivary sample and 89 per cent supplied a stool sample, with high adherence to study instructions, indicating that self-collection of these biospecimens is feasible and acceptable in this age group.
Leung et al., Research in nursing & health (paywalled) · source ↗
Participants preferred the Omnigene and Zymo oral swabs for comfort and ease of use, whilst the Omnigene device yielded the highest median bacterial DNA concentration compared to the other devices. The results indicate that the choice of self-collection device impacts both patient acceptability and DNA yield for oral microbiome analysis.
Rooney et al., Journal of microbiological methods (paywalled) · source ↗
The study demonstrated the feasibility of a fully decentralised design by successfully recruiting 37 participants and completing follow-up for self-collected stool samples without requiring on-site visits.
Feles & Mattner, JMIR research protocols · source ↗
This pilot study found that mailing self-collection kits to endometrial cancer survivors was feasible and acceptable, whilst also observing that chemotherapy or radiation reduced beneficial vaginal bacteria compared to surgery alone.