Stool and vaginal microbiome profiles patterns among Black and White endometrial cancer survivors: A pilot study in North Carolina

In a one-week virtual home clinic with 134 participants, 86 per cent returned saliva and 84 per cent returned stool, and most components were feasible and acceptable despite device and logistical challenges. This supports decentralised, patient-centric self-collection of non-blood biospecimens for research.

Collecting at-Home Biometric Measures for Longitudinal Research From the i3C: Feasibility and Acceptability Study — Russell et al., JMIR human factors · source ↗

• dct
• acceptability
• self-collection
• microbiome
• stool
• saliva
• genotyping

In a cross-sectional study of 90 adolescents, 94 per cent provided at least one salivary sample and 89 per cent supplied a stool sample, with high adherence to study instructions, indicating that self-collection of these biospecimens is feasible and acceptable in this age group.

Engaging adolescents in research: Home self-collection of biological samples and health questionnaires — Leung et al., Research in nursing & health (paywalled) · source ↗

• acceptability
• self-collection
• microbiome
• pediatric
• stool
• saliva

In a community-based cohort of elderly men, remote stool self-collection using the OMNIgene·GUT kit achieved high participation and sample adequacy, with mailed samples yielding high-quality DNA for microbiome profiling; this supports decentralised, patient-centric stool sampling for large-scale research.

Successful collection of stool samples for microbiome analyses from a large community-based population of elderly men — Abrahamson et al., Contemporary clinical trials communications · source ↗

• stool
• stabilised
• dna-genotek-omnigene
• self-collection
• acceptability
• microbiome

Participants preferred the Omnigene and Zymo oral swabs for comfort and ease of use, whilst the Omnigene device yielded the highest median bacterial DNA concentration compared to the other devices. The results indicate that the choice of self-collection device impacts both patient acceptability and DNA yield for oral microbiome analysis.

Comparison of self-collected oral swabs for supragingival microbiome characterization using 16S rRNA gene amplicon sequencing — Rooney et al., Journal of microbiological methods (paywalled) · source ↗

• acceptability
• stabilised
• self-collection
• microbiome
• saliva

Analysis of self-collected stool samples from 309 participants demonstrated that proton pump inhibitor use is significantly associated with an enrichment of Streptococcus species in the gut. This confirms the suitability of decentralised self-sampling for conducting large-scale metagenomic analyses in population studies.

Gut Microbial Variations Associated With Proton Pump Inhibitor Use in the Boston Puerto Rican Health Study — Dinesh et al., Pharmacology research & perspectives · source ↗

• stool
• self-collection
• microbiome