Biomarking Trait Resilience With Salivary Cortisol in Chinese Undergraduates
Lai et al.
The finding, in our words
Self-collected saliva samples taken six times daily across three weekdays from 49 Chinese undergraduates showed that higher trait resilience is associated with a stronger cortisol awakening response and steeper diurnal decline. The protocol, which objectively monitored compliance, supports the feasibility of intensive decentralised sampling for stress-axis biomarker research.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
This study used home self-collected saliva samples to successfully monitor cytokines and cortisol in mothers and infants, finding that a community singing intervention significantly reduced salivary interleukin-6 levels in mothers with postnatal depression.
Kirkpatrick et al., Brain, behavior, and immunity (paywalled) · source ↗
At-home saliva sampling for cortisol was feasible over 12 days in two people with poststroke aphasia, with the cortisol awakening response remaining consistent across days and weeks.
Laures-Gore et al., Journal of speech, language, and hearing research : JSLHR (paywalled) · source ↗
This study found that salivary 11-dehydrodexamethasone correlates strongly with serum dexamethasone, unlike salivary dexamethasone which shows poor agreement. This validation suggests patients could self-collect saliva samples at home to verify dexamethasone absorption for the overnight suppression test.
Marshall et al., The Journal of clinical endocrinology and metabolism (paywalled) · source ↗
This study validated a lateral flow fluorescence assay using quantum dots for saliva and europium nanoparticles for serum to detect cortisol within physiological ranges. The test operates in 15 minutes with a handheld reader, supporting point-of-care and at-home monitoring without a cold chain.
Bruno et al., Journal of fluorescence (paywalled) · source ↗
A validated LC-MS/MS assay successfully measured 13 steroid hormones and two synthetic steroids in saliva, requiring only 50 microlitres, or down to 2 to 5 microlitres for nine analytes. This shows saliva's viability for non-invasive, patient-centric microsampling and decentralised monitoring in paediatric, neonatal and adult populations.
Dahl et al., Scandinavian journal of clinical and laboratory investigation (paywalled) · source ↗