2019 · International journal of biological macromolecules · paywalled
Bioassay of saliva proteins: The best alternative for conventional methods in non-invasive diagnosis of cancer
Eftekhari et al.
The finding, in our words
Salivary protein bioassays, including electrochemical, optical, and DNA-based biosensors, enable sensitive and non-invasive detection of cancer biomarkers without complex sample preparation. These analytical approaches show potential for multiplexed, real-time testing and future home-based diagnostic kits.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
This paper describes a handheld electrochemical sensor for vitamin C measurement in saliva and urine, showing a linear range from 0.2 to 200 µm and detection limit of 0.03 µm. The device demonstrated satisfactory accuracy and recovery in human samples, suggesting potential for affordable home-based testing of vitamin C status.
Fu et al., Advanced healthcare materials (paywalled) · source ↗
The study developed a curcumin-embedded paper sensor for bilirubin detection in saliva, coupled with an IoT-enabled hand-held reader. Clinical testing in 18 jaundiced infants demonstrated good correlation with reference methods for both salivary and blood bilirubin, indicating utility for decentralised neonatal jaundice monitoring.
Golmohammadi et al., ACS sensors (paywalled) · source ↗
A graphene lab-on-a-chip device achieved high accuracy and precision for multiplex renal biomarker testing in serum and saliva, with sensitivities ranging from 89.0 to 99.7 per cent. Untrained volunteers produced results comparable to trained chemists, suggesting the device is suitable for patient-centric at-home diagnostics and could improve access to chronic kidney disease monitoring.
Diforti et al., Analytical chemistry (paywalled) · source ↗
Saliva offers a non-invasive specimen matrix for detecting both oral and systemic conditions at the point of care. Although home collection and diagnostic biosensors show strong clinical and economic utility, technical challenges remain in standardisation and device integration before widespread point-of-care adoption.
Kumari et al., Biomedical materials & devices · source ↗
Electrochemical aptamer biosensors measured glucose and adenosine monophosphate in undiluted saliva with pico- to nanomolar sensitivity and remained reusable for up to seven days after storage. This noninvasive approach could support point-of-care diagnosis and at-home monitoring without the need for blood draws.