Age- and Sex-Specific Reference Intervals for Amino Acids and Acylcarnitines by Tandem Mass Spectrometry in a Kazakhstani Paediatric Population: An Indirect Data-Mining Study
Suleimenov et al.
The finding, in our words
This study derived age- and sex-specific reference intervals for 36 acylcarnitines and amino acids from dried blood spots in 3589 Kazakhstani children by mining 687,726 retrospective laboratory results. The locally validated intervals support decentralised newborn screening interpretation, though the valine upper limit exceeded its clinical decision threshold in neonates, requiring harmonisation.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
Frequent dried blood spot sampling detected early changes in beta-cell function more effectively than mixed-meal tolerance tests or urine ratios, supporting its potential as a decentralised monitoring tool for clinical trials.
Dunseath et al., Diabetes care (paywalled) · source ↗
This review establishes that microsampling across blood, saliva, urine and stool matrices offers validated workflows and regulatory recognition for human biomonitoring comparable to conventional methods. It finds that these decentralised approaches enhance participant acceptability and enable screening in remote or low-resource settings.
Dried blood spot screening of 3210 neonates in an Eastern Indian province found 10.2% had an inherited disorder, most commonly partial biotinidase deficiency (4.5%) and G6PD deficiency (2.7%), with no sex difference except higher 17-OHP in males; the findings justify national newborn screening to reach all communities.
Saharia et al., Journal of tropical pediatrics (paywalled) · source ↗
Positive psychological resources were linked to better self-management behaviour and health-related quality of life in adolescents with type 1 diabetes and high diabetes distress, indicating that interventions focusing on diabetes strengths could improve engagement and wellbeing.
Ream et al., Journal of pediatric psychology (paywalled) · source ↗
A study of 292 patients found that the slopes of home-collected stimulated dried blood spot C-peptide levels over six months predicted 12-month venous mixed-meal tolerance test results, P<0.001. This shows decentralised microsampling can monitor beta-cell function, though further validation is required to confirm its reliability and broader applicability.
Hendriks et al., Diabetes care (paywalled) · source ↗