Acute Dental Pain and Salivary Biomarkers for Stress and Inflammation in Patients with Pulpal or Periapical Inflammation

This study used home self-collected saliva samples to successfully monitor cytokines and cortisol in mothers and infants, finding that a community singing intervention significantly reduced salivary interleukin-6 levels in mothers with postnatal depression.

Community singing intervention reduces maternal salivary cytokines and enhances maternal-infant cortisol synchrony in postnatal depression: biological findings from the SHAPER-PND trial — Kirkpatrick et al., Brain, behavior, and immunity (paywalled) · source ↗

• dct
• cortisol
• self-collection
• pediatric
• hormones
• liquid
• saliva
• biomarkers

A US survey of 3,400 adults aged 62 to 90 collected up to 15 biomeasures at home, including saliva, dried blood spots and urine, with Salivette and Oragene among the devices used, which shows that several patient-centric sampling methods can run together in home-based research.

Continuity and innovation in the data collection protocols of the second Wave of the National Social Life, Health, and Aging Project — Jaszczak et al., The journals of gerontology. Series B, Psychological sciences and social sciences (paywalled) · source ↗

• actigraphy
• multimodal
• blood
• dbs
• cortisol
• dna-genotek-oragene
• self-collection
• dried
• bd-microtainer
• hormones
• liquid
• urine
• saliva
• biomarkers
• genotyping

At-home saliva sampling for cortisol was feasible over 12 days in two people with poststroke aphasia, with the cortisol awakening response remaining consistent across days and weeks.

Intraindividual Variability of the Cortisol Awakening Response, Sleep Dynamics, Stress, and Emotion in Two Persons With Poststroke Aphasia — Laures-Gore et al., Journal of speech, language, and hearing research : JSLHR (paywalled) · source ↗

• cortisol
• self-collection
• hormones
• liquid
• saliva

This study found that salivary 11-dehydrodexamethasone correlates strongly with serum dexamethasone, unlike salivary dexamethasone which shows poor agreement. This validation suggests patients could self-collect saliva samples at home to verify dexamethasone absorption for the overnight suppression test.

The Utility of Salivary 11-Dehydrodexamethasone as a Marker of Dexamethasone Absorption — Marshall et al., The Journal of clinical endocrinology and metabolism (paywalled) · source ↗

• venous-agreement
• tdm
• cortisol
• self-collection
• hormones
• liquid
• validation
• saliva

This study validated a lateral flow fluorescence assay using quantum dots for saliva and europium nanoparticles for serum to detect cortisol within physiological ranges. The test operates in 15 minutes with a handheld reader, supporting point-of-care and at-home monitoring without a cold chain.

Ultrasensitive de novo Protein Sandwich Lateral flow Fluorescence Assay for Cortisol in Saliva and Serum using Quantum dots and Europium Nanoparticles — Bruno et al., Journal of fluorescence (paywalled) · source ↗

• blood
• saliva
• liquid
• self-collection
• validation
• hormones
• cortisol