Aberrant gene expression of superoxide dismutases in Chlamydia trachomatis-infected recurrent spontaneous aborters
Ray et al.
The finding, in our words
First-void urine from women with recurrent spontaneous abortion showed that Chlamydia trachomatis infection was associated with upregulated SOD2 and downregulated SOD1 expression, alongside increased oxidative stress markers 8-hydroxyguanosine and 8-isoprostane, suggesting a role for antioxidant imbalance and ROS detoxification pathways in RSA pathogenesis.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
The study identified differential expression of urine-circulating microRNAs in five Chlamydia trachomatis-positive women with recurrent spontaneous abortion versus controls, with miR-16 showing 4.3-fold upregulation. This supports first-void urine as a viable non-invasive specimen for molecular screening of infection-related reproductive complications in decentralised settings.
Ray et al., Microbial pathogenesis (paywalled) · source ↗
The study found comparable seropositivity for Chlamydia trachomatis and Toxoplasma gondii among male partners of infertile couples in Odisha, with 28 per cent showing anti-Chlamydia IgA and 28 per cent anti-Toxoplasma IgM antibodies. This demonstrates that first-void urine and seminal fluid can detect relevant infections, supporting their use in decentralised fertility screening programmes.
Naik et al., The Indian journal of medical research · source ↗
First-void urine collected via Colli-Pee found no HPV DNA in ocular swabs and no genital-ocular association, refuting autoinoculation in pterygium. Tear VEGF was elevated in pterygium while IL-6, IL-18 and VEGF were raised in dry eye, demonstrating condition-specific cytokine patterns.
Uthaithammarat et al., Scientific reports · source ↗
Vaccine-induced HPV antibodies from cervicovaginal secretions were detectable in first-void urine and correlated with serum levels, so one self-collected urine sample can monitor both HPV infection and immunogenicity without a blood draw; the authors see promise for decentralised follow-up after vaccination.
Among 250 infertile Iranian men, self-collected first-void urine enabled decentralised detection of Chlamydia trachomatis, yet infection status showed no correlation with sperm chromatin condensation or DNA fragmentation. The study validates first-void urine for remote STI screening in fertility assessment, while indicating sperm quality markers are independent of Chlamydia infection.
Dehghan Marvast et al., Andrologia (paywalled) · source ↗