SMA Diagnosis: Detection of SMN1 Deletion with Real-Time mCOP-PCR System Using Fresh Blood DNA

A US survey of 3,400 adults aged 62 to 90 collected up to 15 biomeasures at home, including saliva, dried blood spots and urine, with Salivette and Oragene among the devices used, which shows that several patient-centric sampling methods can run together in home-based research.

Continuity and innovation in the data collection protocols of the second Wave of the National Social Life, Health, and Aging Project — Jaszczak et al., The journals of gerontology. Series B, Psychological sciences and social sciences (paywalled) · source ↗

• actigraphy
• multimodal
• blood
• dbs
• cortisol
• dna-genotek-oragene
• self-collection
• dried
• bd-microtainer
• hormones
• liquid
• urine
• saliva
• biomarkers
• genotyping

This study validated a lateral flow fluorescence assay using quantum dots for saliva and europium nanoparticles for serum to detect cortisol within physiological ranges. The test operates in 15 minutes with a handheld reader, supporting point-of-care and at-home monitoring without a cold chain.

Ultrasensitive de novo Protein Sandwich Lateral flow Fluorescence Assay for Cortisol in Saliva and Serum using Quantum dots and Europium Nanoparticles — Bruno et al., Journal of fluorescence (paywalled) · source ↗

• blood
• saliva
• liquid
• self-collection
• validation
• hormones
• cortisol

In patients with type 2 diabetes and secondary polycythaemia, HbA1c-derived estimated mean plasma glucose showed a significant negative bias compared to structured home capillary blood glucose monitoring, whilst fructosamine served as a more reliable glycaemic marker.

Glycemic assessment in diabetic patients with secondary polycytheamia: limitations of HbA1c and the potential role of fructosamine-a prospective comparative study — Erarslan et al., Acta diabetologica (paywalled) · source ↗

• blood
• haematocrit
• capillary
• liquid
• biomarkers

The homeRNA capillary blood collection and stabilization platform successfully captured lipopolysaccharide-induced inflammatory gene expression profiles. These transcriptomic responses were comparable to those obtained from traditional venous blood samples stabilized with RNAlater or PAXgene, demonstrating the platform's suitability for remote transcriptomic monitoring.

From Home to Transcriptome: Comparing the Transcriptomic Profile of Induced Immune Response via Lipopolysaccharide Stimulation in homeRNA and Venous Blood — Brown et al., Analytical chemistry (paywalled) · source ↗

• venous-agreement
• stabilised
• blood
• capillary
• liquid
• validation
• biomarkers

In pregnant women at high risk of gestational diabetes, the GTT@home capillary glucose device showed a small positive bias of 0.16 mmol/L versus venous laboratory OGTT, with 79.8 per cent of results in the lowest surveillance risk zone and diagnostic classification agreement in 54 of 61 cases, suggesting it could support home OGTT in pregnancy.

Use of the GTT@home Oral Glucose Tolerance Test Kit in Gestational Diabetes Mellitus: Performance Evaluation Study — Dunseath et al., JMIR diabetes · source ↗

• blood
• liquid
• capillary
• validation
• venous-agreement